食品科学

• 营养卫生 • 上一篇    下一篇

玉米胚芽抗氧化肽的急性毒性和致突变性

张鸣镝,赵会燕,刘静波,王 莹,赵骏捷,孙晓萌   

  1. 吉林大学军需科技学院,吉林 长春 130062
  • 出版日期:2014-07-15 发布日期:2014-07-18

Acute Toxicity and Mutagenicity of Corn Germ Antioxidant Peptide

ZHANG Ming-di, ZHAO Hui-yan, LIU Jing-bo, WANG Ying, ZHAO Jun-jie, SUN Xiao-meng   

  1. College of Quartermaster Technology, Jilin University, Changchun 130062, China
  • Online:2014-07-15 Published:2014-07-18

摘要:

研究玉米胚芽抗氧化肽在小鼠体内的急性毒性及致突变性,为其开发应用提供安全保障。采用最大耐受量法、小鼠精子畸形实验、骨髓微核实验和Ames实验对玉米胚芽抗氧化肽进行急性毒性和致突变性研究。结果表明:玉米胚芽抗氧化肽对小鼠的急性经口最大耐受剂量(maximum tolerated dose,MTD)大于34 g/kg(以体质量计);3 项致突变实验结果均为阴性,故玉米胚芽抗氧化肽无急性毒性和致突变性。

关键词: 玉米胚芽抗氧化肽, 精子畸形, 骨髓微核, 鼠伤寒沙门氏菌回复突变实验(Ames实验)

Abstract:

In order to provide safety guarantee for its development and application, the acute toxicity and mutagenicity of
corn germ antioxidant peptide (CGAP) in mice were evaluated by testing maximum tolerable dose (MTD), and mutagenicity
of CGAP was studied by sperm abnormality test, bone marrow cell micronucleus test and Ames test. The results showed that
MTD of CGAP was larger than 34 g/kg in mice and all the results of mutagenicity tests obtained were negative. Thus, CGAP
does not show any acute toxicity or mutagenicity.

Key words: corn germ antioxidant peptide, sperm abnormality, bone marrow cell micronucleus, Salmonella typhimurium reverse mutation test (Ames test)