食品科学

• 营养卫生 • 上一篇    下一篇

抗消化淀粉对昆明小鼠的便秘预防效果

骞 宇,赵 欣   

  1. 重庆第二师范学院生物与化学工程系,重庆 400067
  • 出版日期:2014-08-15 发布日期:2014-08-25

Preventive Effect of Type 3 Resistant Starch (RS3) on Constipation in Kunming Mice

QIAN Yu, ZHAO Xin   

  1. Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China
  • Online:2014-08-15 Published:2014-08-25

摘要:

以抗消化淀粉(resistant starch 3,RS3)为研究对象,建立动物模型,研究其对昆明小鼠便秘的预防效果。结果表明:15% RS3组小鼠表现出最短的首粒黑便排出时间和最高的小肠推进率;而且15% RS3组比10%RS3、5% RS3组小鼠的血清中的胃动素、胃泌素、内皮素、血清乙酰胆碱酯酶、P物质和血管活性肠肽水平升高更明显;生长抑素水平降低更显著;各RS3组小鼠小肠绒毛的断裂更少,其损伤较其他组更轻。综合分析得出,高、中、低含量的RS3对小鼠便秘具有不同程度的预防效果,其中15% RS3的便秘预防效果最佳。

关键词: 抗消化淀粉, 昆明小鼠, 便秘, 胃动素, 血清乙酰胆碱酯酶

Abstract:

The preventive effect of type 3 resistant starch (RS3) on constipation in mice was evaluated by establishing
animal models of constipation. In this study our results showed that dietary substitution of RS3 in a proportion of 15% for
pregelatinized corn flour resulted in the shortest defecation time for the first black stool and the highest gastrointestinal
transit. In addition, compared with 15%, RS3 when used at 10% and 5% increased the levels of serum motilin (MTL), gastrin
(Gas), endothelin (ET), acetylcholinesterase (AchE), substance P (SP), vasoactive intestinal peptide (VIP) and reduced the
level of somatostatin (SS). The intestinal villi of all RS3 groups showed weaker damage and less rupture compared with
the control mice. Collectively these results suggest that dietary supplementation of RS3 diet at three levels has a preventive
effect on constipation in mice, and the best effect is achieved at 15%.

Key words: resistant starch, Kunming mouse, constipation, motilin (MTL), acetylcholine enzyme (AchE)

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