食品科学

• 营养卫生 • 上一篇    下一篇

松花粉对铅中毒小鼠学习和记忆障碍的改善作用

仕薇琳,任紫嫣,曹存凤,王 芳,杨占军   

  1. 淮阴师范学院生命科学学院,江苏 淮安 223300
  • 出版日期:2014-10-15 发布日期:2014-10-17

Improvement of Pine Pollen on Learning and Memory Disorder of Mice Caused by Lead Poisoning

SHI Wei-lin, REN Zi-yan, CAO Cun-feng, WANG Fang, YANG Zhan-jun   

  1. School of Life Science, Huaiyin Normal University, Huai’an 223300 , China
  • Online:2014-10-15 Published:2014-10-17

摘要:

目的:探讨松花粉对铅致中毒小鼠学习和记忆障碍的改善作用。方法:建立小鼠铅中毒模型,用松花粉灌胃进行实验性治疗。持续6 周后,检测小鼠的学习记忆成绩,以及脑组织MDA含量和单胺氧化酶(monoamineoxidase,MAO)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、超氧化物歧化酶(superoxidedismutase,SOD)的活性。结果:与对照组相比,模型组小鼠的学习、记忆能力下降(P<0.05或P<0.01),MDA含量、MAO活性升高(P<0.05或P<0.01),GSH-Px、SOD活性降低(P<0.05);与模型组相比,松花粉组小鼠的学习、记忆能力又不同程度的得到恢复(P<0.05),MDA含量、MAO活性降低(P<0.05),GSH-Px、SOD活性升高(P<0.05)。结论:铅可降低小鼠的学习、记忆能力,而松花粉对铅导致的小鼠学习和记忆障碍有一定的改善作用。

关键词: 松花粉, 铅中毒, 记忆障碍, 改善作用

Abstract:

Objective: To explore the improvement of pine pollen on learning and memory disorder caused by lead poisoning
in mice. Methods: Mouse model of lead poisoning was established and the model mice were experimentally treated with
pine pollen by gavage. After six weeks, the learning and memory ability were evaluated. Meanwhile, MDA content and
monoamine oxidase (MAO), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities in cerebral tissue
were assayed. Results: Compared with the control group, the learning and memory ability of the mice from the model group
were decreased (P < 0.05 or P < 0.01), and the activities of brain GSH-Px and SOD were significantly reduced (P < 0.05),
while MDA content and MAO activity exhibited a significant increase (P < 0.05 or P < 0.01). Compared with the model
group, the learning and memory ability of the mice from the pine pollen group were improved (P < 0.05) and the activities
of GSH-Px and SOD were significantly enhanced (P < 0.05), while MDA content and MAO activity were decreased
(P < 0.05). Conclusion: Lead poisoning can impair learning and memory ability of mice; however, pine pollen can rescue
the impairment of learning and memory.

Key words: pine pollen, lead poisoning, memory disorder, improvement

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