食品科学

• 营养卫生 • 上一篇    下一篇

菊粉对反式脂肪酸致小鼠胰岛素抵抗的影响

李晓月1,张晶晶1,张红建1,周 聪1,肖安红1,2,*   

  1. 1.武汉轻工大学食品科学与工程学院,湖北 武汉 430023;2.湖北省农产品加工与转化重点实验室,湖北 武汉 430023
  • 出版日期:2015-01-15 发布日期:2015-01-16

Effect of Inulin on Insulin Resistance Prevention in Trans Fatty Acids-Fed Mice

LI Xiaoyue1, ZHANG Jingjing1, ZHANG Hongjian1, ZHOU Cong1, XIAO Anhong1,2,*   

  1. 1. College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China;
    2. Hubei Key Laboratory for Agro-processing and Transformation, Wuhan 430023, China
  • Online:2015-01-15 Published:2015-01-16

摘要:

目的:研究菊粉对反式脂肪酸所致小鼠胰岛素抵抗的影响。方法:采用反式脂肪酸饲料诱导建立小鼠高脂血症模型,分别给予低、中、高3 种剂量的菊粉,测定小鼠胰岛素抵抗相关指标。结果:反式脂肪酸的摄入导致小鼠血糖、血清胰岛素水平和胰岛素抵抗指数极显著增加(P<0.01),胰岛素敏感指数、胰岛β细胞功能指数和总超氧化物歧化酶活性极显著降低(P<0.01)。菊粉干预能够降低小鼠血糖水平和胰岛素抵抗指数,提高胰岛素敏感指数和增强胰岛β细胞功能,且菊粉高剂量干预组与反式脂肪酸组相比,差异均极显著(P<0.01),效果最好。结论:反式脂肪酸能够导致小鼠胰岛素抵抗,菊粉干预能够改善小鼠的胰岛素抵抗状况,且高剂量组效果最好。

关键词: 反式脂肪酸, 菊粉, 小鼠, 胰岛素抵抗, 高脂血症

Abstract:

Objective: To evaluate the effect of inulin on insulin resistance in trans fatty acids-fed mice. Methods: Inulin was
given at low, medium and high doses. Results: The intake of trans fatty acids elevated fasting blood glucose, fasting serum
insulin, insulin resistance index significantly (P < 0.01), and reduced insulin sensitivity index, islet β-cell function and T-SOD
significantly (P < 0.01). Inulin reduced fasting blood glucose and insulin resistance index, and increased insulin sensitivity
index and islet β-cell function, especially at the high dose, showing significant differences (P < 0.01) when compared with
the trans fatty acid group. Conclusion: Trans fatty acids can lead to insulin resistance in mice, and the intervention of inulin
can improve the symptoms, in particular at the high dose.

Key words: trans fatty acids, inulin, mice, insulin resistance, hyperlipidemia

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