食品科学

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围氏马尾藻岩藻聚糖硫酸酯对高脂血症小鼠脂质代谢的调节作用

谌素华1,王维民1,*,蔡 璐1,钟思燕1,钟赛意1,谢恩义2   

  1. 1.广东省水产品加工与安全重点实验室,广东普通高等学校水产品深加工重点实验室,广东海洋大学食品科技学院,广东 湛江 524088;2.广东海洋大学水产学院,广东 湛江 524088
  • 出版日期:2015-10-15 发布日期:2015-10-20

Regulatory Effects of Sargassum wightii Fucoidan on Lipid Metabolism of Hyperlipidemic Mice

CHEN Suhua1, WANG Weimin1,*, CAI Lu1, ZHONG Siyan1, ZHONG Saiyi1, XIE Enyi2   

  1. 1. Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Key Laboratory of Advanced Processing of
    Aquatic Products of Guangdong Higher Education Institution, College of Food Science and Technology, Guangdong Ocean University,
    Zhanjiang 524088, China; 2. College of Fisheries, Guangdong Ocean University, Zhanjiang 524088, China
  • Online:2015-10-15 Published:2015-10-20

摘要:

目的:研究不同分子质量围氏马尾藻(Sargassum wigtii)岩藻聚糖硫酸酯对高脂血症小鼠脂质代谢的影响。方法:建立高脂血症小鼠模型,给小鼠灌胃中、低分子质量岩藻聚糖硫酸酯(MMWF1、MMWF2和LMWF1、LMWF2),测定小鼠体质量和肝脏指数以及血清脂质指标总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(high density lipoprotein cholesterol,LDL-C)含量,测定肝脏脂质指标TC、TG含量,探索岩藻聚糖硫酸酯的降脂效果。结果:灌胃4 种不同分子质量的岩藻聚糖硫酸酯对高脂血症小鼠的体质量增长无显著影响,高剂量的4 种岩藻聚糖硫酸酯可明显降低高脂血症小鼠的肝脏指数(P<0.05)。4 种岩藻聚糖硫酸酯具有显著降低高脂血症小鼠血清和肝脏TG、TC、LDL-C含量(P<0.05),提高HDL-C含量(P<0.05)的作用,对动脉粥样硬化指数(atherosclerosis index,AI)也有明显降低效果(P<0.05),具有预防动脉粥样硬化生成的作用。结论:4 种岩藻聚糖硫酸酯能够有效降低高脂血症小鼠血清和肝脏TC、TG含量,调节脂质代谢,有效缓解高脂血症,高剂量组作用最显著,剂量依赖性较明显。

关键词: 围氏马尾藻, 岩藻聚糖硫酸酯, 高脂血症, 脂质代谢

Abstract:

The objective of this study was to examine the effects of Sargassum wightii fucoidans with different molecular
weights on lipid metabolism of hyperlipidemic mice. Hyperlipidemic mouse models were established by gavaging medium
molecular weight fractions (MMWF1 and MMWF2) and low molecular weight fractions (LMWF1 and LMWF2) of
Sargassum wightii fucoidan. The body weights and liver indices of mice were measured. Serum indices such as total
cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol
(LDL-C) and liver TC and TG levels were determined. The efficacy of Sargassum wightii fucoidan for reducing blood lipids
was examined. Sargassum wightii fucoidan with four different molecular weights did not result in an obvious increase in
body weights of experimental mice but at the high dosage significantly reduced liver indices of the mice (P < 0.05). All
four fucoidan fractions from Sargassum wightii significantly reduced serum TG, TC and LDL-C levels and liver TC and
TG levels (P < 0.05) and increased serum HDL-C level (P < 0.05) of hyperlipidemic mice. They also significantly reduced
atherosclerosis index (AI) and prevented the occurrence of atherosclerosis (P < 0.05), effectively reduced TC and TG levels,
regulated lipid metabolism and effectively alleviated hyperlipidemia. Sargassum wightii fucoidan at the high dose revealed
the most significant blood lipid-reducing effect in a dose-dependent manner.

Key words: Sargassum wightii, fucoidan, hyperlipidemia, lipid metabolism

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