食品科学

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基于蛋白质组学的植物多酚抗肿瘤作用机制研究进展

李 谣1,廖 霞1,肖星凝1,张小利1,卢可可1,吴素蕊2,明 建1,3,*   

  1. 1.西南大学食品科学学院,重庆 400715;2.中华全国供销合作总社昆明食用菌研究所,云南 昆明 650223;3.重庆市特色食品工程技术研究中心,重庆 400715
  • 出版日期:2016-02-15 发布日期:2016-02-26

Progress in Research on the Antitumor Mechanisms of Plant Polyphenols Based on Proteomics

LI Yao1, LIAO Xia1, XIAO Xingning1, ZHANG Xiaoli1, LU Keke1, WU Surui2, MING Jian1,3,*   

  1. 1. College of Food Science, Southwest University, Chongqing 400715, China;
    2. Kunming Edible Fungi Institute, All China Federation of Supply and Marketing Cooporatives, Kunming 650223, China;
    3. Chongqing Engineering Research Center of Regional Food, Chongqing 400715, China
  • Online:2016-02-15 Published:2016-02-26

摘要:

蛋白质组学(proteomics)作为一种大规模研究细胞蛋白质功能的重要技术和研究方法,广泛应用在揭示肿瘤发病分子机制、寻找生物标志物、筛选治疗新药物等方面。植物多酚作为一种天然活性物质,已经证实具有抗肿瘤潜力。本文对蛋白质组学及运用蛋白质组学技术和研究方法探讨植物多酚抗肿瘤作用机制进行了综述,以期为植物多酚保健食品、药品的开发提供一定的科学依据。

关键词: 植物多酚, 蛋白质组学, 抗肿瘤, 分子机制

Abstract:

Proteomics, an important method for the large-scale study of cellular proteins, has been widely used for exploring
the molecular mechanisms of cancer, searching for biomarkers, and screening for new anticancer drugs. The antitumor
potential of plant polyphenols, as natural active substances, has been confirmed. This paper provides an overview of
proteomics and reviews recent progress in proteomic studies of the antitumor mechanisms of plant polyphenols, aiming to
provide a scientific basis for the application of plant polyphenols in health food and drugs.

Key words: plant polyphenols, proteomics, antitumor, molecular mechanism

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