食品科学

• 专题论述 • 上一篇    下一篇

枸杞多糖防治2型糖尿病的机制研究进展

夏 惠1,唐华丽1,2,潘佳琪1,孙桂菊1,*   

  1. 1.东南大学公共卫生学院,江苏 南京 210009;2.重庆三峡学院生命科学与工程学院,重庆 404000
  • 出版日期:2016-05-15 发布日期:2016-05-18

Current Progress in the Understanding of the Mechanism of Prevention and Treatment of Lycium barbarum Polysaccharides on Type 2 Diabetes

XIA Hui1, TANG Huali1,2, PAN Jiaqi1, SUN Guiju1,*   

  1. 1. School of Public Health, Southeast University, Nanjing 210009, China;
    2. College of Life Science and Engineering, Chongqing Three Gorges University, Chongqing 404000, China
  • Online:2016-05-15 Published:2016-05-18

摘要:

本文总结了枸杞多糖对2型糖尿病的作用,研究表明枸杞多糖能够有效地降低血糖、血脂,促进胰岛素分泌,改善胰岛素抵抗,增加胰岛素敏感性,改善超氧化物歧化酶、丙二醛、一氧化氮等氧化应激指标,其作用机制可能与改善糖尿病靶器官胰岛功能有关,比如上调胰岛素受体底物-1、调节糖代谢相关的基因,并且对糖尿病并发症有一定的防治作用。

关键词: 枸杞多糖, 2型糖尿病, 降血糖, 降血脂, 胰岛素分泌, 糖尿病并发症

Abstract:

The present review summarizes therapeutic effects of Lycium barbarum polysaccharides (LBP) on type 2 diabetes.
Research indicated that LBP treatment could lower blood glucose and lipid levels, facilitate insulin secretion, attenuate
insulin resistance and increase insulin sensitivity. Furthermore, superoxide dismutase activity (SOD), malondialdehyde
(MDA) level, nitrogen monoxide (NO) content and other oxidative stress indicators could be significantly improved by LBP
administration. The mechanism may be associated with the improvement of pancreas islet function, such as upregulation
of insulin receptor substrate-1 and regulation of genes related to glycometabolism. LBP also has potential preventive and
therapeutic effects on diabetes complications.

Key words: Lycium barbarum polysaccharides, type 2 diabetes, blood glucose-lowering, blood lipid-lowering, insulin secretion, diabetes complications

中图分类号: