食品科学 ›› 2017, Vol. 38 ›› Issue (21): 207-211.doi: 10.7506/spkx1002-6630-201721033

• 营养卫生 • 上一篇    下一篇

蓝莓花青素对小鼠抗疲劳及体内抗氧化作用

张卓睿,毛迪锐,高晗,魏青青,蔡冲   

  1. (1.北华大学林学院,吉林?吉林 132013;2.吉林省长白山食品药品检测检验中心,吉林?延边 133613)
  • 出版日期:2017-11-15 发布日期:2017-11-01
  • 基金资助:
    吉林市科技计划项目(2015431015);2016年国家级大学生创新项目(201610201013)

Anti-Fatigue and Antioxidant Effects of Anthocyanins from Blueberry in Mice

ZHANG Zhuorui, MAO Dirui, GAO Han, WEI Qingqing, CAI Chong   

  1. (1. Forestry College of Beihua University, Jilin 132013, China; 2. Jilin Province Changbai Mountain Food and Drug Inspection Testing Center, Yanbian 133613, China)
  • Online:2017-11-15 Published:2017-11-01

摘要: 目的:研究蓝莓花青素对小鼠抗疲劳和体内抗氧化的作用。方法:经灌胃给予小鼠低、中、高剂量蓝莓花青素30?d后,分别测定负重游泳时间、转棒时间,肝糖原(liver glycogen,LG)含量、肌糖原(muscle glycogen,MG)含量、血尿素氮(blood urea nitrogen,BUN)含量、血乳酸(blood lactic acid,BLA)含量、乳酸脱氢酶(lactic dehydrogenase,LDH)活力、肝脏总抗氧化能力(total antioxidant capacity,T-AOC)、总超氧化物歧化酶(total superoxide dismutase,T-SOD)活力、谷胱甘肽过氧化物歧化酶(glutathione peroxide dismutase,GSH-Px)活力及丙二醛(malondialdehyde,MDA)含量。结果:与空白对照组相比,蓝莓花青素低、中、高剂量组能显著延长小鼠负重游泳时间和转棒时间(P<0.05,P<0.01),蓝莓花青素低、中、高剂量组能使小鼠体内LG含量显著增加(P<0.05),BLA、BUN和MDA含量明显降低(P<0.05,P<0.01),并能显著增加小鼠肝脏T-AOC和T-SOD、GSH-Px活力(P<0.05)。蓝莓花青素中、高剂量组能使小鼠体内MG含量和LDH活力显著增加(P<0.05,P<0.01)。结论:结果表明蓝莓花青素具有较好的抗疲劳及体内抗氧化作用。

关键词: 蓝莓, 花青素, 抗疲劳, 抗氧化

Abstract: Objective: This work investigated the anti-fatigue and antioxidant effects of blueberry anthocyanins in mice. Methods: Mice were administrated with low, medium and high doses of blueberry anthocyanins by gavage for 30 days. After that, weight-loaded swimming time, rota-rod endurance time, and the levels of liver glycogen (LG), muscle glycogen (MG), blood urea nitrogen (BUN), blood lactic acid (BLA), serum lactate dehydrogenase (LDH), and liver total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), malondialdehyde (MDA), and glutathione peroxide dismutase (GSH-Px). Results: Compared with the blank control group, blueberry anthocyanins at all doses significantly prolonged weight-loaded swimming time and rota-rod endurance time (P < 0.05, P < 0.01), increased LG content (P < 0.05), decreased BLA, BUN and MDA contents (P < 0.05, P < 0.01), and improved the activity of liver T-AOC, T-SOD and GSH-Px in mice (P < 0.05). Blueberry anthocyanins at medium and high doses could noticeably improve LDH activity and MG content in mice (P < 0.05, P < 0.01). Conclusion: Blueberry anthocyanins have good anti-fatigue and anti-oxidant effects in vivo.

Key words: blueberry, anthocyanins, anti-fatigue, antioxidant

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