食品科学 ›› 2019, Vol. 40 ›› Issue (19): 326-333.doi: 10.7506/spkx1002-6630-20181004-009

• 专题论述 • 上一篇    下一篇

黄酮类化合物干预糖尿病视网膜病变的研究进展

黄永杰,李锋,李大鹏   

  1. (山东农业大学食品科学与工程学院,山东省高校食品加工技术与质量控制重点实验室,山东 泰安 271018)
  • 出版日期:2019-10-15 发布日期:2019-10-25
  • 基金资助:
    国家自然科学基金面上项目(31571836);国家自然科学基金青年科学基金项目(31201417); 山东省现代农业产业技术体系蜂产业创新团队项目(SDAIT-24-05);山东省“双一流”建设项目(SYT2017XTTD04)

Recent Progress in the Application of Flavonoids in the Intervention of Diabetic Retinopathy

HUANG Yongjie, LI Feng, LI Dapeng   

  1. (Key Laboratory of Food Processing Technology and Quality Control of Shandong Higher Education Institutes, College of Food Science and Engineering, Shandong Agricultural University, Tai’an 271018, China)
  • Online:2019-10-15 Published:2019-10-25

摘要: 糖尿病视网膜病变是糖尿病患者中最常见的微血管并发症,也是全世界造成失明的主要原因之一。人体内活性氧过量产生导致的氧化损伤是糖尿病视网膜病变的主要发病机制。黄酮类化合物普遍存在于植物膳食中,具有抗氧化、抗炎、降血糖、清除自由基等多种生理活性。近年来,越来越多的研究表明,黄酮类化合物对糖尿病视网膜病变有显著的干预效果。本文综述了近年来国内外对黄酮类化合物抗糖尿病视网膜病变的研究进展,以期为黄酮类化合物的进一步开发和应用提供理论参考和研究思路。

关键词: 糖尿病视网膜病变, 植物膳食, 黄酮类化合物, 活性氧, 氧化应激

Abstract: Diabetic retinopathy is the most common microvascular complication in diabetic patients, and it is also one of the leading causes of blindness worldwide. It is evidenced that oxidative damage induced by excessive reactive oxygen species in the body is the major pathogenesis of diabetic retinopathy. Flavonoids, present ubiquitously in plant diets, have many pharmacological functions such as antioxidant, anti-inflammatory, hypoglycemic and free radical scavenging activities. Recently, increasing evidence has shown the significant role of flavonoids in preventing and treating diabetic retinopathy. In this paper, recent progress in the study of the anti-diabetic retinopathy potential of flavonoids is summarized with the aim of providing a theoretical basis and new ideas for further development and application of flavonoids.

Key words: diabetic retinopathy, plant diets, flavonoids, reactive oxygen species, oxidative stress

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