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### 沉积固化离子液体均相液液微萃取-高效液相色谱法测定蔬菜中的苯脲类农药残留

1. （长春工业大学化学与生命科学学院，吉林 长春 130012）
• 出版日期:2020-02-25 发布日期:2020-03-02
• 基金资助:
国家自然科学基金青年科学基金项目（21401011）；吉林省教育厅“十三五”科学技术项目（JJKH20181014K）

### Homogeneous Liquid-Liquid Microextraction Based on the Solidification of Sedimentary Ionic Liquid Coupled with High Performance Liquid Chromatography for the Determination of Phenylurea Residues in Vegetables Samples

XU Weili, FU Zhuang, WANG Xu, ZHAO Yue, WANG Chenzhao, MA Jiajun, WANG Zhibing

1. (College of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, China)
• Online:2020-02-25 Published:2020-03-02

Abstract: In this study, an analytical method using homogeneous liquid-liquid microextraction based on the solidification of sedimentary ionic liquid coupled with high performance liquid chromatography (HPLC) was developed and applied to the simultaneous determination of five phenylurea pesticide residues in vegetables. The hydrophilic ionic liquid noctyltributylphosphonium bromide ([P4448]Br) was used as the microextraction solvent. The extraction was carried out with the aid of ultrasound, after centrifugation and cooling. The analytes were enriched into the ionic liquid phase and deposited at the bottom of the centrifuge tube. The ionic liquid phase was diluted and used for chromatographic analysis. The combined use of one-factor-at-a-time method and Box-Behnken design response surface methodology was proposed to optimize the important extraction conditions. The experimental results showed that the regression models for the target analytes were all significant (P > 0.05). Good linearity with correlation coefficients greater than 0.998 1 was obtained under the optimum conditions. The limits of detection (LODs) and limits of quantification (LOQs) were in the range of 2.19–5.35 and 7.30–17.82 μg/kg, respectively. The recoveries for spiked samples were between 82.84% and 117.49% with relative standard deviations (RSDs) lower than 9.93%. The present method has the advantages of less solvent consumption, environmental protection and simple operation and thus can be used for the extraction and detection of phenylurea pesticide residues in vegetables.