白桦脂酸与红枣总三萜酸对小鼠酒精肝损伤的保护作用

doi:10.7506/spkx1002-6630-201811030

食品科学 ›› 2018, Vol. 39 ›› Issue (11): 191-195.doi: 10.7506/spkx1002-6630-201811030

白桦脂酸与红枣总三萜酸对小鼠酒精肝损伤的保护作用

蔡天娇，王瑞珍，魏君慧，薛媛，雷宏杰*，徐怀德*

西北农林科技大学食品科学与工程学院，陕西杨凌 712100

出版日期:2018-06-15 发布日期:2018-06-06
基金资助:
陕西省难题攻关项目（2013KTZB02-03-04）

Protective Effects of Betulinic Acid and Total Triterpenic Acids from Red Jujubes on Alcoholic Liver Injury in Mice

CAI Tianjiao, WANG Ruizhen, WEI Junhui, XUE Yuan, LEI Hongjie*, XU Huaide*

College of Food Science and Engineering, Northwest A & F University, Yangling 712100, China

Online:2018-06-15 Published:2018-06-06

摘要/Abstract

摘要： 为研究白桦脂酸与红枣总三萜酸对小鼠酒精肝损伤的保护作用，通过白酒灌胃小鼠建立酒精性肝损伤模型，测定小鼠体质量、肝脏指数及相关生化指标，并取肝脏制作苏木精-伊红染色切片，观测肝组织的病理学变化。结果表明，白桦脂酸与红枣总三萜酸均可降低酒精性肝损伤小鼠肝脏指数、血清谷丙转氨酶和谷草转氨酶活力以及甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平，显著提高高密度脂蛋白胆固醇水平、肝脏谷胱甘肽过氧化物酶、超氧化物歧化酶活力（P＜0.05），同时使肝脏丙二醛水平显著下降（P＜0.05），肝组织病理损伤也得到明显改善。白桦脂酸和红枣总三萜酸对酒精性肝损伤具有明显保护作用。

关键词: 白桦脂酸, 红枣, 总三萜酸, 酒精性肝损伤, 保护作用

Abstract: The protective effects of betulinic acid (BA) and total triterpenic acids from red jujube (JTTA) on alcoholic liver injury in mice were investigated. A mouse model of alcoholic liver injury was established by intragastrically treating mice with alcohol. Body weight, liver index and relevant biochemical indicators were determined. Histopathological changes in the liver were detected by staining liver sections with hematoxylin and eosin. The results showed that BA and JTTA could reduce liver index, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in serum, increase high-density lipoprotein cholesterol (HDL-C) levels in serum and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities, and decrease malondialdehyde (MDA) levels in liver tissue significantly (P < 0.05). Furthermore, BA and JTTA could repair pathological liver injury. The results demonstrated that BA and JTTA could protect the liver from alcohol-induced injury.

Key words: betulinic acid, red jujube, total triterpenic acids, alcoholic liver injury, protective effect

中图分类号:

TS201.2

蔡天娇，王瑞珍，魏君慧，薛媛，雷宏杰，徐怀德. 白桦脂酸与红枣总三萜酸对小鼠酒精肝损伤的保护作用[J]. 食品科学, 2018, 39(11): 191-195.

CAI Tianjiao, WANG Ruizhen, WEI Junhui, XUE Yuan, LEI Hongjie, XU Huaide. Protective Effects of Betulinic Acid and Total Triterpenic Acids from Red Jujubes on Alcoholic Liver Injury in Mice[J]. FOOD SCIENCE, 2018, 39(11): 191-195.

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白桦脂酸与红枣总三萜酸对小鼠酒精肝损伤的保护作用

Protective Effects of Betulinic Acid and Total Triterpenic Acids from Red Jujubes on Alcoholic Liver Injury in Mice

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