食品科学 ›› 2020, Vol. 41 ›› Issue (5): 128-134.doi: 10.7506/spkx1002-6630-20181114-155

• 营养卫生 • 上一篇    下一篇

米醋醋粕通过抑制脂质吸收降低仓鼠脂肪细胞尺寸和改善高脂血症

佟立涛,鞠志远,耿栋辉,王丽丽,周闲容,周素梅   

  1. (中国农业科学院农产品加工研究所,农业农村部农产品加工重点实验室,北京 100193)
  • 出版日期:2020-03-15 发布日期:2020-03-23
  • 基金资助:
    教育部留学回国基金项目([2013]1792);国家自然科学基金青年科学基金项目(31401505)

Rice Vinegar Residue Reduces Adipocyte Size and Hyperlipidemia by Inhibiting Lipids Absorption in Hamsters

TONG Litao, JU Zhiyuan, GENG Donghui, WANG Lili, ZHOU Xianrong, ZHOU Sumei   

  1. (Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agro-products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China)
  • Online:2020-03-15 Published:2020-03-23

摘要: 米醋醋粕作为米醋生产的副产物被大量废弃,但其在调节脂质代谢方面具有潜在的作用。本研究旨在探讨米醋醋粕对高胆固醇血症仓鼠脂质代谢的影响。用200、500 mg/(kg mb·d)剂量的米醋醋粕以及米醋灌胃仓鼠30 d。米醋醋粕和米醋均能显著降低血浆低密度脂蛋白胆固醇浓度(P<0.05),降低白色脂肪组织的平均脂肪细胞体积,增加粪便中甘油三酯、总胆固醇和胆汁酸浓度(P<0.05)。同时,米醋醋粕能破坏肠道胆固醇向胶束的形成(P<0.05),并抑制其与胆酸盐的结合(P<0.05),但是米醋醋粕对脂肪酶活性没有明显的抑制作用。结果表明,米醋醋粕通过阻止胆固醇在肠内的吸收,促进粪脂的排泄和肝脏中合成的胆固醇来发挥降血脂功效,对脂质代谢和肥胖具有有益的调节作用。

关键词: 米醋醋粕, 高胆固醇血症, 脂肪细胞体积, 粪便脂质, 脂质吸收

Abstract: Rice vinegar residue, a by-product of rice vinegar making, is wasted in enormous quantity, which has been believed to have potential effects in the regulation of lipid metabolism. This study aimed to investigate the effects of rice vinegar residue on lipid metabolism in hypercholesterolemic hamsters. Rice vinegar residue at doses of 200 and 500 mg/(kg mb·d) and rice vinegar at 200 mg/(kg mb·d) were separately given by gavage to hamsters for 30 days. Both rice vinegar residue and rice vinegar significantly lowered the concentration of low-density lipoprotein cholesterol in plasma (P < 0.05), reduced the average size of adipocytes in white adipose tissues, and increased the fecal concentrations of triglycerides, total cholesterol and bile acids (P < 0.05). Moreover, vinegar residue disrupted solubilization of intestinal cholesterol into micelles (P < 0.05), as well as inhibited its binding to cholate (P < 0.05). On the other hand, vinegar residue had no inhibitory effect on lipase activity. Eventually, we conclude that rice vinegar residue has potential beneficial effects on lipid metabolism and obesity by preventing the absorption of cholesterol in the intestine and promoting the excretion of fecal lipids and cholesterol synthesis in the liver, which may be related to the combination between vinegar residue and cholate.

Key words: rice vinegar residue, hypercholesterolemia, adipocyte size, fecal lipids, lipid absorption

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