食品科学 ›› 2019, Vol. 40 ›› Issue (21): 311-316.doi: 10.7506/spkx1002-6630-20181127-309

• 专题论述 • 上一篇    下一篇

多糖受体与巨噬细胞吞噬作用关系研究进展

赵丽,金周雨,荆波,宋慧   

  1. (1.吉林农业大学生命科学学院,吉林 长春 130118;2.吉林农业大学 教育部食药用菌工程研究中心,吉林 长春 130118)
  • 出版日期:2019-11-15 发布日期:2019-12-02
  • 基金资助:
    吉林省科技厅安全高效新型饲料产品研发项目(20180201019NY)

Recent Progress in the Relationship between Polysaccharide Receptor and Macrophage Phagocytosis

ZHAO Li, JIN Zhouyu, JING Bo, SONG Hui   

  1. (1. School of Life Sciences, Jilin Agricultural University, Changchun 130118, China; 2. Engineering Research Center of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun 130118, China)
  • Online:2019-11-15 Published:2019-12-02

摘要: 近年来,多糖作为免疫调节剂通过巨噬细胞表面受体介导的免疫调节作用得到广泛关注,巨噬细胞表面多糖受体成为众学者的研究热点。巨噬细胞属于免疫细胞,在机体免疫中可参与介导炎症反应、修复组织损伤、识别并吞噬病原体等过程。巨噬细胞的吞噬作用起始于对胞吞物的识别,这与巨噬细胞表面受体密切相关。有研究表明多糖能促进巨噬细胞吞噬作用,但其机制尚不明确。本文仅对巨噬细胞表面多糖受体与巨噬细胞吞噬作用之间的关系进行综述,以期为今后多糖激活细胞吞噬作用的研究提供参考依据。

关键词: 多糖, 免疫, 多糖受体, 巨噬细胞, 吞噬作用

Abstract: In recent years, polysaccharides have been widely used as immunomodulators in the regulation of macrophage surface receptor-mediated immunoregulation. Polysaccharide receptors on the surface of macrophages have become a research hotspot. Macrophages belong to immune cells and participate in mediating inflammation, repairing tissue damage, and recognizing and phagocytizing pathogens. The phagocytosis of macrophages begins with the recognition of endocytosis, which is closely related to macrophage surface receptors. Studies have shown that polysaccharides can promote macrophage phagocytosis, but the underlying mechanism is yet unclear. In this review, we explore the relationship between polysaccharide receptors on the macrophage surface and macrophage phagocytosis, which will provide useful information for future studies of polysaccharide-activated cell phagocytosis.

Key words: polysaccharide, immunity, polysaccharide receptor, macrophage, phagocytosis

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