食品科学 ›› 2020, Vol. 41 ›› Issue (1): 196-202.doi: 10.7506/spkx1002-6630-20181207-088

• 营养卫生 • 上一篇    下一篇

两株乳酸菌对高脂模型大鼠的益生作用

朱婕旭,高利娥,黄文康,李文苑,马莹,郭旭生,丁梓桐   

  1. (兰州大学生命科学学院,益生菌与生物饲料研究中心,甘肃 兰州 730000)
  • 出版日期:2020-01-15 发布日期:2020-01-19
  • 基金资助:
    兰州市人才创新创业项目(2016-RC-55);兰州大学中央高校基本科研业务费重点项目(lzujbky-2017-k15)

Probiotic Effects of Two Lactobacillus Strains in Rats Fed a High-Fat Diet

ZHU Jiexu, GAO Li’e, HUANG Wenkang, LI Wenyuan, MA Ying, GUO Xusheng, DING Zitong   

  1. (Probiotics and Bio-feed Research Centre, School of the Life Sciences, Lanzhou University, Lanzhou 730000, China)
  • Online:2020-01-15 Published:2020-01-19

摘要: 为探究两株筛选自青藏高原传统发酵牦牛酸奶乳酸菌高脂模型大鼠体内的益生作用。通过前期体外实验发现,菌株BX-1是一株产胆盐水解酶的瑞士乳杆菌,而BX56是一株不产胆盐水解酶的罗伊氏乳杆菌。大鼠体内灌胃实验结果显示,灌胃瑞士乳杆菌BX-1能够显著降低大鼠血清和肝脏胆固醇及甘油三酯水平(P<0.05),同时能够减少脂类物质在大鼠肝脏组织内的沉积,促进体内脂质的排泄,而灌胃罗伊氏乳杆菌BX56在大鼠体内降血脂的效果并不明显。结果表明瑞士乳杆菌BX-1具有良好降胆固醇效果,具有潜在的治疗高脂血症的作用。

关键词: 乳酸菌, 大鼠, 降胆固醇活性, 益生作用

Abstract: The objective of this study was to investigate the probiotic effects of two cholesterol-lowering lactic acid bacterial strains isolated from traditional fermented yak milk in the Tibetan plateau in rats fed a high-fat diet. It has been proved that Lactobacillus helveticus BX-1 could produce bile salt hydrolase while Lactobacillus reuteri BX56 could not. Administration of strain BX-1 could significantly reduce cholesterol and triglycerides in the serum and liver of rats (P < 0.05), reduce lipid deposition in the liver, and accelerate the excretion of lipids at the same time. However, BX56 had no significant effect in lowering cholesterol in rats. Overall, BX-1 has a good cholesterol-lowering capacity and may have a potential in hyperlipidemia treatment.

Key words: lactic acid bacteria, rats, cholesterol-lowering activity, probiotics

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