食品科学 ›› 2020, Vol. 41 ›› Issue (1): 318-329.doi: 10.7506/spkx1002-6630-20181213-169

• 专题论述 • 上一篇    

胶红酵母生产生物活性物质研究进展

庄荣玉,王如晨,邱晓挺,车嘉豪,李勇勇,张蔚筱,杨文鸽,史咏梅,吴祖芳   

  1. (1.宁波大学食品与药学学院,浙江 宁波 315800;2.浙江省动物蛋白食品精深加工重点实验室,浙江 宁波 315800)
  • 出版日期:2020-01-15 发布日期:2020-01-19
  • 基金资助:
    宁波市科技局科技富民项目(2017C10034);浙江省科技厅公益技术应用研究计划项目(2017C33009)

Bioactive Substances Produced by Rhodotorula mucilaginosa: A Comprehensive Review

ZHUANG Rongyu, WANG Ruchen, QIU Xiaoting, CHE Jiahao, LI Yongyong, ZHANG Weixiao, YANG Wenge, SHI Yongmei, WU Zufang   

  1. (1. College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China; 2. Key Laboratory of Animal Protein Foods Deep Processing of Zhejiang Province, Ningbo 315800, China)
  • Online:2020-01-15 Published:2020-01-19

摘要: 胶红酵母为红酵母属物种,具有较强的环境适应力,广泛存在于不同生态系统环境中。其菌体含有蛋白质、天然类胡萝卜素、β-胡萝卜素、虾青素、多不饱和脂肪酸和维生素等多种营养成分和生物活性物质,是很有潜力的工业生产菌株。本文重点综述了胶红酵母在番茄红素、β-胡萝卜素、虾青素和ω-3系列的α-亚麻酸功能性食用油脂等生物活性物质领域的应用研究进展,主要包括高产菌株筛选、基因工程菌株的构建、发酵工艺和提取工艺等,介绍了其在共培养漆酶、角质酶和全细胞生物转化先导化合物制备新型药物方面的应用。

关键词: 胶红酵母, 类胡萝卜素, α-亚麻酸, ω-3多不饱和脂肪酸, 漆酶, 角质酶, 生物催化剂

Abstract: The red yeast Rhodotorula mucilaginosa is a species belonging to the genus Rhodotorula. It is widely distributed in various ecosystems because of its strong adaptability to different environments. R. mucilaginosa appears to be a very promising industrial strain due to its ability to produce proteins and bioactive substances such as natural carotenoids, β-carotene, astaxanthin, polyunsaturated fatty acids (PUFA) and vitamins. This review summarizes the available data in the literature on the research and application of R. mucilaginosa in the production of lycopene, β-carotene, astaxanthin and alpha-linolenic acid and functional edible oils rich in the essential dietary ω-3 fatty acid, α-linolenic acid (ALA). Its focus is on screening for high-yield strains, construction of genetically engineered strains, and the fermentation and extraction processes as well as the applications of R. mucilaginosa in production of laccase by co-culture, cutinase and in the preparation of novel drugs from whole-cell biotransformation lead compounds.

Key words: Rhodotorula mucilaginosa, carotenoid, alpha-linolenic acid, ω-3 polyunsaturated fatty acid, laccase, cutinase, biocatalyst

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