食品科学 ›› 2020, Vol. 41 ›› Issue (9): 86-90.doi: 10.7506/spkx1002-6630-20190422-294

• 营养卫生 • 上一篇    下一篇

甘蔗醋对高脂小鼠血脂代谢及组织氧化还原的影响

李志春,陈赶林,郑凤锦,孙健,林波,方晓纯   

  1. (1.广西壮族自治区农业科学院农产品加工研究所,广西 南宁 530007;2.广西果蔬贮藏与加工新技术重点实验室,广西 南宁 530007;3.广西农业科学院/中国农业科学院甘蔗研究中心,广西 南宁 530007)
  • 出版日期:2020-05-15 发布日期:2020-05-15
  • 基金资助:
    国家星火计划项目(2015GA790013);广西科技计划项目(桂科AB16380244); 南宁市科技计划项目(20171120-1);南宁市西乡塘区科技计划项目(201720103); 广西农业科学院基本科研业务专项(桂农科2018YT28)

Effect of Sugarcane Vinegar on Lipid Metabolism and Redox State of Mice Fed High-Fat Diet

LI Zhichun, CHEN Ganlin, ZHENG Fengjin, SUN Jian, LIN Bo, FANG Xiaochun   

  1. (1. Agro-food Science and Technology Research Institute, Guangxi Academy of Agricultural Sciences, Nanning 530007, China; 2. Guangxi Key Laboratory of Fruits and Vegetables Storage-Processing Technology, Nanning 530007, China; 3. Guangxi Academy of Agricultural Sciences/Sugarcane Research Center, Chinese Academy of Agricultural Sciences, Nanning 530007, China)
  • Online:2020-05-15 Published:2020-05-15

摘要: 甘蔗醋中含有丰富的黄酮和酚类物质,具有较强的抗氧化能力,本实验通过建立高脂膳食诱发血脂代谢紊乱小鼠模型,探究甘蔗醋对高脂膳食诱导的血脂代谢紊乱小鼠的血脂、肝脂和谷胱甘肽过氧化物(glutathione peroxidase,GSH-Px)、丙二醛(malondialdehyde,MDA)、一氧化氮合酶(nitric oxide synthase,NOS)、超氧化物歧化酶(superoxide dismutase,SOD)水平的影响。结果表明:与高脂对照组相比,灌胃甘蔗醋可显著降低高脂小鼠血浆总胆固醇水平(P<0.05),极显著降低甘油三酯、低密度脂蛋白胆固醇水平(P<0.01)和升高高密度脂蛋白的水平(P<0.01),同时极显著降低淀粉酶活力(P<0.01)和增加脂肪酶活力(P<0.01),减少血糖的浓度和脂肪的累积,还能够提高血浆及肝脏中SOD、GSH-Px活力,降低NOS活力和肝脏中脂质过氧化反应产物MDA含量。甘蔗醋能正向调节血脂水平、预防体质量和脏器质量增加、提高抗氧化应激能力,从而有助于抑制高血脂、肥胖及其并发症的进一步发展。

关键词: 甘蔗醋, 血脂代谢, 氧化应激, 高脂小鼠

Abstract: Sugarcane vinegar contains abundant polyphenols and flavonoids and has good antioxidant activity. Given this background, this study explored the effect of sugarcane vinegar on blood lipids, liver lipids and redox capacity including the activity of glutathione peroxidase (GSH-Px), nitric oxide synthase (NOS) and superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in a mouse model of lipid metabolism disorder induced by a high-fat diet. The results showed that compared with the high fat control group, oral administration with sugarcane vinegar could significantly decrease plasma total cholesterol (TC) (P < 0.05), lower triglyceride (TG) and low-density lipoprotein cholesterol (P < 0.01) and increase high-density lipoprotein cholesterol (P < 0.01). At the same time, blood ?amylase activity was significantly decreased (P < 0.01) and lipase activity was significantly increased (P < 0.01), so that blood glucose level and fat accumulation could be reduced. The activity of SOD and GSH-Px in plasma and liver were improved, and NOS activity and MDA content of the lipid peroxidation products in liver were decreased. Therefore, sugarcane vinegar can function to regulate blood lipids, reduce body mass and hepatomegaly and improve oxidative stress resistance, thereby helping slow down the occurrence and development of hyperlipidemia, and obesity and its complications.

Key words: sugarcane vinegar, lipid metabolism, oxidative stress, mice fed high-fat diet

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