食品科学 ›› 2020, Vol. 41 ›› Issue (13): 169-173.doi: 10.7506/spkx1002-6630-20190702-030

• 营养卫生 • 上一篇    下一篇

甜玉米芯多糖对糖尿病大鼠的降血糖作用

马永强,张凯,王鑫,路雪纯,林枞雨   

  1. (1.哈尔滨商业大学食品工程学院,黑龙江 哈尔滨 150076;2.哈尔滨工业大学生命科学与技术学院,黑龙江 哈尔滨 150080)
  • 出版日期:2020-07-15 发布日期:2020-07-29
  • 基金资助:
    哈尔滨商业大学研究生创新基金项目(YJSCX2018-543HSD);黑龙江省哈尔滨商业大学校级科研项目(17XN022)

Hypoglycemic Effect of Sweet Corn Cob Polysaccharide on Diabetic Rats

MA Yongqiang, ZHANG Kai, WANG Xin, LU Xuechun, LIN Congyu   

  1. (1. College of Food Engineering, Harbin University of Commerce, Harbin 150076, China;2. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China)
  • Online:2020-07-15 Published:2020-07-29

摘要: 甜玉米芯多糖(SCP-80-1)是从甜玉米穗轴中提取的物质,具有很好的体外降血糖作用。但SCP-80-1对糖尿病大鼠的降血糖作用尚未进行评估。本研究用链脲佐菌素(streptozotocin,STZ)诱导糖尿病大鼠模型后,分别以100、200、400 mg/kg mb剂量的SCP-80-1灌胃小鼠28 d,并设置200 mg/kg mb的二甲双胍阳性药物组。分别测定大鼠空腹血糖浓度、葡萄糖耐受量、胰岛素含量、血脂指标、脏器指数并观察胰腺组织切片情况。结果表明:SCP-80-1可降低STZ诱导的糖尿病大鼠空腹血糖水平及餐后血糖水平,并改善糖尿病大鼠的葡萄糖耐受量水平;SCP-80-1还可通过降低糖尿病大鼠的总胆固醇、甘油三酯、低密度脂蛋白胆固醇浓度以及提高高密度脂蛋白胆固醇浓度来改善血脂水平;此外,SCP-80-1对脏器肿胀具有一定程度的减轻作用,并对STZ诱导的糖尿病大鼠胰岛组织具有一定的修复作用,同时可提高胰岛B细胞数量。结论:SCP-80-1可以有效调节糖尿病大鼠的血糖水平,改善葡萄糖耐受程度,修复损伤的胰岛组织,表明其是一种具有一定开发潜力和研究价值的天然降糖物质,在糖尿病治疗中的应用具有广阔前景。

关键词: 糖尿病, 甜玉米芯多糖, 降血糖, 血脂水平, 胰腺组织

Abstract: We have previously prepared a polysaccharide from sweet corn cobs named SCP-80-1 and have demonstrated it to have a good hypoglycemic effect in vitro. In this study, we evaluated the hypoglycemic effect of SCP-80-1 on streptozotocin (STZ)-induced diabetic rats. The diabetic animals were administered intragastrically with SCP at doses of 100, 200 and 400 mg/kg mb or metformin at 200 mg/kg mb for 28 days. The fasting blood glucose, glucose tolerance, insulin content, blood lipids, visceral organ indices and pancreatic tissue sections were measured. The results showed that SCP-80-1 could decrease the fasting blood glucose level and postmeal blood glucose level, and improve the glucose tolerance of diabetic rats. It was also found that SCP-80-1 could improve blood lipid levels by reducing the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol and increasing the level of high-density lipoprotein cholesterol. In addition, SCP-80-1 could reduce organ swelling to a certain extent, repair the damaged islet tissue, and increase the number of islet B cells. Therefore, SCP-80-1 can effectively regulate the blood glucose level of diabetic rats, improve glucose tolerance and repair the injured islet tissue, indicating that this polysaccharide is a natural hypoglycemic agent that is promising for application in the treatment of diabetes mellitus.

Key words: diabetes mellitus, sweet corn cob polysaccharide, hypoglycemia, blood lipid level, pancreatic tissue

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