关键词: 溴酸钾, 微核, 染色体, 精子

Abstract: Objective:Through the discussion of mutagenicity of mice born marrow polychromatic erythrocyte,born marrow cell chromosome and sperm shape abnormality induced by potassium bromate to expound its toxicity. Methods:50 Kunming mice( half of female and male ) were randomly divided into five groups:1/2 LD50,1/4 LD50 and1/8 LD50,the three dosage groups as well as negative control and positive control. The negative control group was given equal-volume distilled water,and the positive control group was conducted by abdominal cavity injection 40 mg cyclophosphamide /kg bw. The three dosage groups were conducted by gavage for four days to observe effects on frequency of mice born marrow polychromatic erythrocyte by potassium bromate. 40 Kunming mice(half of female and male) were randomly divided into five groups,and the negative control group and the positive control group were treated as the above method. Effects of potassium bromate on mice marrow cell chromosome distortion situation were observed by gastric administration to the three dosage groups for two days. To observe effect of potassium bromate on mice sperm,grouping of mice and establishment of model were the same as the experiments on mice marrow cell chromosome distortion situation basically,except gastric administration for five days. Results:Compared with negative control group,there are extremely significant differences on frequency of mice born marrow polychromatic erythrocyte,born marrow cell chromosome and sperm shape abnormality of the three dosage groups(p<0.01). Conclusions:Potassium bromate can induce obvious mutagenic action. It is a chromosome clastogen and can cause teratospermia. The results showed that potassium bromate has potential inherent toxicity.

Key words: potassium bromate, micronucleus, chromosomes, spermatozoa