食品科学

• 营养卫生 • 上一篇    下一篇

大枣多糖对慢性疲劳综合症大鼠的作用效果

邵长专,唐 刚   

  1. 上海海事大学体育部,上海 201306
  • 出版日期:2015-01-15 发布日期:2015-01-16

Preventive Effect of Jujube Polysaccharide on Chronic Fatigue Syndrome in Rats

SHAO Changzhuan, TANG Gang   

  1. Department of Sport, Shanghai Maritime University, Shanghai 201306, China
  • Online:2015-01-15 Published:2015-01-16

摘要:

目的:揭示大枣多糖(jujube polysaccharide,JP)对慢性疲劳综合症(chronic fatigue syndrome,CFS)的预防作用。方法:采用水提醇沉法对JP进行制备,同时建立大鼠CFS模型,通过服用不同剂量的JP,对大鼠的行为学方面进行检测,测定血清超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathioneperoxidase,GSH-Px)活性,丙二醛(malonaldehyde,MDA)水平以及脾脏指数、胸腺指数、T淋巴细胞转化情况。结果:JP能够显著提高脾脏指数,降低血清MDA含量,改善T淋巴细胞的转化能力。结论:JP对于CFS的预防效果与其调节机体的免疫能力及改善抗氧化能力有关。

关键词: 大枣多糖, 慢性疲劳, 免疫, 抗氧化

Abstract:

Objective: To reveal the preventive effect of jujube polysaccharides (JP) on chronic fatigue syndrome (CFS).
Methods: JP were prepared from jujube fruits by water extraction and ethanol precipitation and their physicochemical
properties were determined. A four-week old rat CFS model was established. The rats were orally administrated with JP
and the behavior experiments were conducted after induction of CFS. The activities of superoxide dismutase (SOD) and
glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA) in rat serum were eassayed. Spleen index,
thymus index and T lymohocyte transformation were analyzed. Results: JP markedly decreased MDA levels in serum, and
increased spleen index and T lymohocyte transformation. Conclusions: The preventive effects of JP on CFS are closely
related to their immune-regulating function and antioxidant activity.

Key words: jujube polysaccharide, chronic fatigue, immune, antioxidant

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