三丁酸甘油脂对宫内发育迟缓哺乳仔猪血液生理生化指标和胰腺的影响

doi:10.7506/spkx1002-6630-201605027

食品科学

三丁酸甘油脂对宫内发育迟缓哺乳仔猪血液生理生化指标和胰腺的影响

何进田1，董丽1,2，白凯文1，牛玉1，寇涛1，杨敏馨1，张莉莉1，王恬1,*

1.南京农业大学动物科技学院，江苏南京 210095；2.扬州大学动物科学与技术学院，江苏扬州 225009

出版日期:2016-03-15 发布日期:2016-03-17

Effect of Tributyrin on Blood Physiobiochemical Indices and Pancrea of Sucking Piglets with Intra-Uterine Growth Retardation

HE Jintian1, DONG Li1,2, BAI Kaiwen1, NIU Yu1, KOU Tao1, YANG Minxin1, ZHANG Lili1, WANG Tian1,*

1. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China;
2. College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Online:2016-03-15 Published:2016-03-17

摘要/Abstract

摘要：

研究宫内发育迟缓（intra-uterine growth retardation，IUGR）对哺乳仔猪血液生理生化指标、胰腺质量及其分泌酶活性的影响，以及日粮添加0.1%三丁酸甘油酯对其调控作用。选取8 头正常初生体质量仔猪和16 头IUGR仔猪，将IUGR仔猪随机均分为2 组，分别饲喂基础人工乳（IUGR组）、基础人工乳＋0.1%三丁酸甘油酯（IUGR＋tributyrin，IT组），正常仔猪饲喂基础人工乳（NBW组）。7 日龄开始饲喂，21 日龄时每组选取6 头体质量相近的仔猪屠宰取样，并对血液指标和胰腺酶活力进行测定。结果表明：1）受IUGR影响，仔猪血液中尿素、总胆红素含量显著降低（P＜0.05），总蛋白、肌酐含量显著上升（P＜0.05）；胰腺质量也较NBW组显著降低（P＜0.05）；胰淀粉酶、脂肪酶活力显著降低（P＜0.05）。2）IUGR仔猪日粮补充0.1%三丁酸甘油酯后，血液中尿素、总胆红素、总蛋白、肌酐与NBW组相比，均无显著差异（P＞0.05）；且胰腺质量得到增加（P＞0.05），胰蛋白酶、胰淀粉酶和脂肪酶含量均显著提高（P＜0.05）。结果提示：IUGR可对哺乳仔猪血液生理生化造成一定的影响和阻碍胰腺的发育以及酶活性的分泌，日粮补充0.1%三丁酸甘油酯能对IUGR造成的损伤有一定的缓解作用。

关键词: 宫内发育迟缓, 胰腺, 哺乳仔猪, 血液生理生化指标

Abstract:

The main objective of this experiment was to evaluate the regulatory effect of dietary supplementation of
tributyrin at 0.1% on blood physiological and biochemical indexes, pancreas weight, and pancreatic enzyme secretion in
sucking piglets with intrauterine growth retardation (IUGR). Totally 8 normal-birth-weight piglets and 16 IUGR piglets were
selected. The IUGR piglets were randomly divided into 2 groups (IUGR group was fed basic artificial milk; IUGR+tributyrin
group fed basic artificial milk supplemented with 0.1% tributyrin). The normal-birth-weight piglets fed with basic artificial
milk (NBW group). The experiment started from 7 days and ended at 21 days of age. Then, 6 piglets with nearly equal
body weight were selected from each group and slaughtered. Blood parameters and pancreatic enzyme activities were
detected. The results showed that the levels of blood total bilirubin and urea were significantly decreased (P < 0.05), and
total protein and creatinine were significantly increased (P < 0.05) in IUGR piglets. The pancreas weights of IUGR piglets
were significantly lower (P < 0.05) than those of the NBW group. Pancreatic amylase and lipase activities in IUGR piglets
were significantly decreased (P < 0.05). Moreover, after being supplemented with 0.1% tributyrin, blood urea, total bilirubin,
total protein and creatinine in IUGR piglets had no significant difference (P > 0.05) from those in the NBW group. Pancreas
weight was increased (P > 0.05), trypsin, amylase and lipase were significantly increased (P < 0.05) in IUGR piglets. The
above findings suggested that blood physiological and biochemical indices of sucking piglets could be influenced by IUGR.
Dietary supplementation of 0.1% tributyrin has a potential therapeutic role in attenuating the damage caused by IUGR.

Key words: intrauterine growth retardation (IUGR), pancreas, sucking piglets, blood physiological and biochemical parameters

中图分类号:

TS202.3

何进田，董丽，白凯文，牛玉，寇涛，杨敏馨，张莉莉，王恬. 三丁酸甘油脂对宫内发育迟缓哺乳仔猪血液生理生化指标和胰腺的影响[J]. 食品科学, doi: 10.7506/spkx1002-6630-201605027.

HE Jintian, DONG Li, BAI Kaiwen, NIU Yu, KOU Tao, YANG Minxin, ZHANG Lili, WANG Tian. Effect of Tributyrin on Blood Physiobiochemical Indices and Pancrea of Sucking Piglets with Intra-Uterine Growth Retardation[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201605027.

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三丁酸甘油脂对宫内发育迟缓哺乳仔猪血液生理生化指标和胰腺的影响

Effect of Tributyrin on Blood Physiobiochemical Indices and Pancrea of Sucking Piglets with Intra-Uterine Growth Retardation

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