食品科学

• 营养卫生 • 上一篇    下一篇

马齿苋籽油的抗氧化和抗肿瘤细胞增殖作用

郭 改1,岳 丽1,范少丽1,敬思群1,*,晏良军2   

  1. 1.新疆大学生命科学与技术学院,新疆 乌鲁木齐 830046;
    2.北德克萨斯大学健康科学中心药物科学系,美国 德克萨斯 沃斯堡 76107
  • 出版日期:2017-02-15 发布日期:2017-02-28

Antioxidant and Antiproliferative Activities of Portulaca oleracea L.Seed Oil

GUO Gai1, YUE Li1, FAN Shaoli1, JING Siqun1,*, YAN Liangjun2   

  1. 1. College of Life Sciences and Technology, Xinjiang University, Ürümqi 830046, China; 2. Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center at Fort Worth, Fort Worth 76107, USA
  • Online:2017-02-15 Published:2017-02-28

摘要: 对马齿苋籽油(Portulaca oleracea L. seed oil,PSO)的体外抗氧化和抗增殖活性进行评价,同时对PSO在马油贮存过程中对其酸败的延缓效果进行考察。通过测定PSO的总还原力、·OH及1,1-二苯基-2-三硝基苯肼自由基的清除率来评价其抗氧化效果,并测定不同处理组马油的过氧化值。结果表明:PSO具有较强的抗氧化活性,且随着剂量的增加而增加,并且PSO能有效延缓马油脂质氧化。3-(4,5-二甲基噻唑-2)-2,5-二苯基四氮唑溴盐法检测PSO对宫颈癌细胞HeLa、食管癌细胞Eca-109、乳腺癌细胞MCF-7及非洲绿猴肾细胞Vero体外细胞增殖效果的影响。结果表明:PSO对肿瘤细胞增殖有较强的抑制作用,且抑制作用随着时间和剂量的增加而增强。因此,PSO有望成为市场上人工合成抗氧化剂的取代物用于食品保藏,同时也可作为食品和化妆品工业的主要成分。

关键词: 马齿苋籽油, 抗氧化, 抗增殖, 保藏

Abstract: The purpose of this study was to assess the antioxidant and antitumor activities of Portulaca oleracea L. seed oil (PSO) in vitro and its application to delay rancidity of horse oil. We determined the reducing power of PSO and its scavenging effects on hydroxyl radicals (·OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and assessed its stability during horse oil storage with its addition. The results showed that PSO had remarkable, dose-dependent antioxidant activity, and could effectively prevent lipid oxidation in horse oil. We treated cervical cancer HeLa cells, human esophageal carcinoma Eca-109 cells and human breast adenocarcinoma MCF-7 cells with PSO using non-neoplastic monkey kidney Vero cells as control. The results indicated that PSO significantly inhibited tumor cell proliferation in a time-and dosedependent manner. Our findings suggest that PSO can be a substitute for synthetic antioxidants in food preservation and may be potentially useful as a food or cosmetic ingredient.

Key words: Portulaca oleracea L. seed oil (PSO), antioxidant, anti-proliferation, preservation

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