多孔淀粉对卵巢切除大鼠脂质代谢的影响

doi:10.7506/spkx1002-6630-201703035

食品科学

多孔淀粉对卵巢切除大鼠脂质代谢的影响

张晶1，陈兵1，陈朝军2，刘雄1,*

1.西南大学食品科学学院，重庆 400715；2.贵州省马铃薯研究所，贵州贵阳 550006

出版日期:2017-02-15 发布日期:2017-02-28

Effect of Dietary Porous Starch on Lipid Metabolism in Ovariectomized Rats

ZHANG Jing1, CHEN Bing1, CHEN Zhaojun2, LIU Xiong1,*

1. College of Food Science, Southwest University, Chongqing 400715, China; 2. Guizhou Potato Institute, Guiyang 550006, China

Online:2017-02-15 Published:2017-02-28

摘要/Abstract

摘要： 目的：研究多孔淀粉对卵巢切除大鼠脂质代谢的影响。方法：将24 只雌性SD大鼠按体质量随机分为3 组，其中一组进行伪切除手术，其余两组进行双侧卵巢切除手术，手术后恢复1 周，分别饲喂相应饲料。4 周后，检测大鼠血脂、肝脂、粪便中中性固醇含量和胆汁酸含量以及肠道中典型微生物数量、短链脂肪酸浓度等指标。结果：多孔淀粉的替代添加可以显著降低大鼠血浆中甘油三酯（triglyceride，TG）、TG与高密度脂蛋白胆固醇（high-density lipoprotein cholesterol，HDL-C）的比值（TG/HDL-C）、肝脏中总胆固醇（total cholesterol，TC）、TG和脂肪总质量，显著减少腹部脂肪堆积（P＜0.05）；显著增加粪便中中性固醇和胆汁酸的排泄量（P＜0.05）；同时促进肠道中益生菌增殖和短链脂肪酸浓度的提高。结论：多孔淀粉对雌激素缺乏引起的高脂血症具有较好的降脂、降胆固醇效果，对内源性脂质代谢紊乱具有较好的缓解作用。

关键词: 多孔淀粉, 卵巢切除大鼠, 血脂, 胆固醇

Abstract: To investigate the effect of dietary porous starch on lipid metabolism in ovariectomized rats, 24 mature female SD rats were randomly divided into 3 groups according to body weight: Sham-operated group and two bilaterally ovariectomized (OVX) groups. From one week after the operation onwards, the rats from each group were given the corresponding diet. The contents of triglyceride (TG) and cholesterol in plasma and liver, neutral sterols and bile acids in feces, and microorganisms and short chain fatty acids (SCFAs) in cecal contents were determined after 4 weeks of feeding. Results indicated that triglyceride (TG) and TG/high-density lipoprotein cholesterol (HDL-C) ratio in plasma, total cholesterol (TC), TG and total fat in liver, and abdominal fat deposition were significantly reduced by dietary substitution of porous starch (P < 0.05). The excretion of neutral sterols and bile acids in feces were increased significantly (P < 0.05). Meanwhile, porous starch also promoted the proliferation of probiotic microorganisms, and increased the concentration of SCFAs. In conclusion, porous starch may decrease the risk of suffering hyperlipidemia due to the lack of estrogen.

Key words: porous starch, ovariectomized rat, plasma lipids, cholesterol

中图分类号:

TS201.4

张晶，陈兵，陈朝军，刘雄. 多孔淀粉对卵巢切除大鼠脂质代谢的影响[J]. 食品科学, doi: 10.7506/spkx1002-6630-201703035.

ZHANG Jing, CHEN Bing, CHEN Zhaojun, LIU Xiong. Effect of Dietary Porous Starch on Lipid Metabolism in Ovariectomized Rats[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201703035.

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多孔淀粉对卵巢切除大鼠脂质代谢的影响

Effect of Dietary Porous Starch on Lipid Metabolism in Ovariectomized Rats

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