食品科学 ›› 2019, Vol. 40 ›› Issue (11): 338-342.doi: 10.7506/spkx1002-6630-20180507-110

• 专题论述 • 上一篇    下一篇

益生菌对神经系统疾病作用的研究进展

王娜娜,霍贵成,李 春,陆婧婧,李艾黎*   

  1. 东北农业大学食品学院,黑龙江 哈尔滨 150030
  • 出版日期:2019-06-15 发布日期:2019-06-28
  • 基金资助:
    黑龙江应用技术研究与开发计划项目(GA16B201);黑龙江省自然科学基金项目(C2018022);“十三五”国家重点研发计划项目(2018YFD0502404)

Recent Progress in Research on Probiotics Effect on Nervous System Diseases

WANG Nana, HUO Guicheng, LI Chun, LU Jingjing, LI Aili*   

  1. School of Food Science, Northeast Agricultural University, Harbin 150030, China
  • Online:2019-06-15 Published:2019-06-28

摘要: 人体肠道内菌群数量巨大且种类丰富,参与机体的多项生理过程,研究显示肠道菌群能够通过肠道菌群-肠-脑轴来调节机体大脑的发育与行为。益生菌是一类对人体有益的活性微生物,可以通过调节人体肠道微生态平衡从而对人体产生有益作用。临床医学研究表明,益生菌对自闭症谱系障碍、阿尔茨海默病、帕金森病、抑郁症和多发性硬化等神经系统疾病具有良好的防治作用。本文总结了近几年来国内外关于益生菌对神经系统疾病作用机制的研究进展,以期为益生菌对此类疾病的干预治疗提供新思路。

关键词: 益生菌, 肠道菌群, 神经系统疾病, 机制

Abstract: The gut microbiome in humans consists of a vast and diverse population of microbes that is involved in many physiological processes. Many studies have demonstrated that the gut microbiome regulates the development and behavior of human brain through the microbiota-gut-brain axis. Probiotics are a group of live microorganisms that are beneficial to the human body by regulating the micro-ecological balance in the human intestinal tract. Clinical studies have shown that probiotics are highly effective in the prevention and treatment of autism spectrum disorders, Alzheimer’s disease, Parkinson’s disease, depression and multiple sclerosis and other neurological diseases. In this article, recent progress understanding in the mechanism of action of probiotics on nervous system diseases in China and abroad is reviewed in order to provide a new idea for the intervention and treatment of diseases using probiotics.

Key words: probiotics, gut microbiome, nervous system diseases, mechanism

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