食品科学 ›› 2009, Vol. 30 ›› Issue (9): 210-212.doi: 10.7506/spkx1002-6630-200909051

• 营养卫生 • 上一篇    下一篇

余甘子提取物对糖尿病小鼠血糖的影响

韩 刚,原海忠,董 月,翟冠玉,范 颖   

  1. 华北煤炭医学院药学系,唐山市新药基础研究重点实验室
  • 收稿日期:2008-08-25 修回日期:2008-12-29 出版日期:2009-05-01 发布日期:2010-12-29
  • 通讯作者: 韩刚 E-mail:tsyxhg@163.com

Blood Glucose-reducing Effects of Fructus phyllanthi Fruit Extracts on Diabetic Mice

HAN Gang YUAN Hai-zhong DONG Yue ZHAI Guan-yu FAN Ying   

  1. Tangshan Key Laboratory of New Drug Research, Pharmaceutical Department, North China Coal Medical
    University, Tangshan 063000, China
  • Received:2008-08-25 Revised:2008-12-29 Online:2009-05-01 Published:2010-12-29
  • Contact: HAN Gang E-mail:tsyxhg@163.com

摘要:

目的:研究余甘子提取物对糖尿病小鼠血糖的影响。方法:采用小鼠尾静脉注射70mg/kg四氧嘧啶建立小鼠糖尿病模型。分别灌胃给予二甲双胍阳性对照药物、余甘子乙醇提取物、余甘子水提取物,测定糖尿病小鼠血糖浓度的变化。结果:与糖尿病模型组比较,余甘子水提取物降血糖作用明显(p<0.05),余甘子乙醇提取物仅有降血糖趋势,无统计学意义(p>0.05)。结论:余甘子水提取物对四氧嘧啶所致糖尿病小鼠具有显著的降血糖的作用(p<0.05)。

关键词: 余甘子, 糖尿病, 血糖, 四氧嘧啶

Abstract:

In this study, diabetic mice model was established by intravenous injection of 70 mg/kg alloxan. Then the mice were administered with metformin (the positive control), and ethanol extract and aqueous extract of Fructus pyhlllanthi fruit by gastric perfusion, respectively, to investigate the effects of ethanol and aqueous extracts on blood glucose level of diabetic mice. The results showed that the aqueous extract can significantly decrease the blood glucose level in diabetic mice (p<0.05), but there is only a hypoglycemic tendency induced by ethanol extract without statistical significance (p>0.05).

Key words: Fructus phyllanthi, diabetes mellitus, blood glucose, alloxan

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