食品科学 ›› 2009, Vol. 30 ›› Issue (7): 236-238.doi: 10.7506/spkx1002-6630-200907054

• 营养卫生 • 上一篇    下一篇

螺旋藻对衰老小鼠学习、记忆障碍的改善作用

杨占军   

  1. 淮阴师范学院生物系
  • 收稿日期:2008-07-06 修回日期:2008-10-13 出版日期:2009-04-01 发布日期:2010-12-29
  • 通讯作者: 杨占军 E-mail:yzj5678@163.com

Improving Effect of Spirulina on Learning and Memory Disturbance in Aging Mice

YANG Zhan-jun   

  1. (Department of Biology, Huaiyin Normal College, Huai an 223300, China)
  • Received:2008-07-06 Revised:2008-10-13 Online:2009-04-01 Published:2010-12-29
  • Contact: YANG Zhan-jun E-mail:yzj5678@163.com

摘要:

目的:探讨螺旋藻对D-半乳糖所致学习、记忆障碍的改善作用。方法:使用D-半乳糖建立小鼠衰老模型,用螺旋藻灌胃进行实验性治疗。持续6w后,通过跳台实验、避暗实验和Morris水迷宫实验检测小鼠的学习记忆能力。结果:与对照组相比,模型组小鼠的学习、记忆能力下降(p<0.05或p<0.01);与模型组相比,治疗组的学习、记忆能力又不同程度的得到恢复 (p<0.05)。结论:螺旋藻可改善由D-半乳糖所导致的学习、记忆障碍。

关键词: 螺旋藻, 衰老, 记忆障碍, 改善作用

Abstract:

Effect of Spirulina on learning and memory disturbance on aging mice model induced by D-galactose by gavage was investigated. Following by six-week administration, the ability of learning and memory was assessed by step-down test, dark avoidance test, water-maze spatial localization task. Results indicated that the ability of learning and memory in model group decreases (p<0.05 or p<0.01), and this ability is recovered in different degrees following by Spirulina feeding (p<0.05). In conclusion, Spirulina is favorable for the recovery of learning and memory disturbance in aging mice.

Key words: Spirulina, aging, memory disturbance, improvement

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