食品科学 ›› 2009, Vol. 30 ›› Issue (1): 246-248.doi: 10.7506/spkx1002-6630-200901058

• 营养卫生 • 上一篇    下一篇

摄食壳聚糖对小鼠体内铅水平的影响

覃彩芹1,2,曾林涛1,李 伟2   

  1. 1.孝感学院天然多糖研究室 2.武汉大学 生物质资源化学与环境生物技术湖北省重点实验室
  • 收稿日期:2008-01-25 出版日期:2009-01-01 发布日期:2010-12-29
  • 通讯作者: 覃彩芹 E-mail:qincq@sohu.com
  • 基金资助:

    国家自然科学基金项目(20472066);湖北省教育厅科研重大项目(Z200626001)

Effect of Dietary Chitosan on Level of Lead in Mice

QIN Cai-qin1,2, ZENG Lin-tao1, LI Wei2   

  1. (1.Laboratory of Natural Polysaccharides, Xiaogan University, Xiaogan 432000, China ;2.Key Laboratory of Biomass-Resource
    Chemistry and Environmental Biotechnology of Hubei, Wuhan University, Wuhan 430072, China)
  • Received:2008-01-25 Online:2009-01-01 Published:2010-12-29
  • Contact: QIN Cai-Qin E-mail:qincq@sohu.com

摘要:

采用壳聚糖含量为1.05% 的饲料喂食小鼠90d,喂食的四种壳聚糖分别是高分子量壳聚糖(HCS)(重平均分子量Mw7.60 × 105,脱乙酰度(DDA) 85.5%、中分子量壳聚糖(MCS)(Mw3.27 × 104,DDA85.2%)、壳寡糖(COS)(Mw0.99 × 103,DDA 85.7%)和水溶性壳聚糖(WSC)(Mw3.91 × 104, DDA52.6%)。喂养期间,小鼠无非正常症状和死亡发生。实验结果表明,喂食HCS 对小鼠的肝、脾、心脏和肾脏中的铅含量几乎无影响,COS 和WSC使小鼠的肝、脾和心脏中的铅含量有所降低。但是,MCS 却明显增加了肝脏中铅含量。

关键词: 壳聚糖, 小鼠,

Abstract:

1.05% of 4 kinds of dietary chitosans with different molecular weights (Mw) and degrees of deacetylation (DDA) (high molecular weight chitosan HCS with Mw 7.60×105 and DDA 85.5%, middle molecular weight chitosan MCS with Mw 3.27×104 and DDA 85.2%, chitooligomer COS with Mw 0.99×103 and DDA 85.7%, and water-soluble chitosan WSC with Mw 3.91×104 and DDA 52.6%) were fed to mice for 90 days. No abnormal symptoms, clinical signs or deaths were observed during the feeding period. The body weights of mice between chitosan groups and control group show no significant difference. HCS almost has no effect on the levels of lead in liver, spleen, heart and kidney. COS and WSC decrease the levels of lead in liver, spleen and heart. However, MCS significantly increases the level of lead in liver.

Key words: chitosan, mouse, lead

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