食品科学 ›› 2009, Vol. 30 ›› Issue (19 ): 286-290.doi: 10.7506/spkx1002-6630-200919067

• 营养卫生 • 上一篇    下一篇

精制蜂胶对小鼠免疫功能的影响

付俊鹤1,余 宙1,*,胡居吾2,陈 娟1   

  1. 1.南昌大学中德联合研究院 2.江西省科学院
  • 收稿日期:2009-06-12 出版日期:2009-10-01 发布日期:2010-12-29
  • 通讯作者: 余 宙1,*, E-mail:yuzhou@ncu.edu.cn

Effects of Refined Propolis on Immune Function in Mice

FU Jun-he1,YU Zhou1,*,HU Ju-wu2,CHEN Juan1   

  1. 1.Sino-Germany Joint Research Institute, Nanchang University, Nanchang 330047, China;
    2. Jiangxi Academy of Sciences, Nanchang 330029, China
  • Received:2009-06-12 Online:2009-10-01 Published:2010-12-29
  • Contact: YU Zhou1,*, E-mail:yuzhou@ncu.edu.cn

摘要:

本实验拟研究精制蜂胶对小鼠免疫功能的影响。采用45、90、135mg/kg bw 剂量的精制蜂胶给小鼠经口灌胃30d,分别测定免疫器官脏器/ 体重比值,进行迟发型变态反应、ConA 诱导的小鼠淋巴细胞转化实验、抗体生成细胞检测、半数溶血值测定、小鼠碳廓清实验和NK细胞活性的测定。 结果发现:与阴性对照组比较,135mg/kg bw剂量能明显提高小鼠的迟发型变态反应的能力,能明显提高胸腺体重比值、小鼠抗体生成细胞数、半数溶血值,明显增强小鼠单核- 巨噬细胞碳廓清能力,明显提高小鼠NK 细胞活性,证明精制蜂胶具有潜在增强免疫力的作用。

关键词: 精制蜂胶, 脏器体重比值, 碳肌酸清能力, NK 细胞活性, 免疫功能

Abstract:

In order to study the effects of refined propolis on immune function of normal mice, spleen/body and thymus/body weight ratios, delayed type hypersensitivity (DTH), lymphocyte transformation capacity induced by ConA, antibody forming spleen cells (AFPC), 50% hemolytic concentration and carbon clearance ability, NK cell activity were determined after mice were orally administered with refined propolis at doses of 45, 90 and 135 mg/kg. bw for 30 days. Compared with the control group, refined propolis at dose of 135 mg/kg.bw could significantly enhance thymus/body weight ratio, DTH; increase AFPC and HC50, carbon clearance capacity of mononuclear-macrophages, NK cell activity and lymphocyte transformation capacity induced by ConA in mice. These results indicate that refined propolis can improve immune function in mice.

Key words: refined propolis, thymus/body weight ratio, carbon clearance ability, NK cell activity, immune function

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