减肥保健食品中非法添加盐酸西布曲明的检测

食品科学 ›› 2008, Vol. 29 ›› Issue (2): 340-343.

减肥保健食品中非法添加盐酸西布曲明的检测

曹玲, 张妤琳, 王宝珠

江苏省药品检验所；江苏省药品检验所江苏南京210008；江苏南京210008；

出版日期:2008-02-15 发布日期:2011-08-24

Identification and Determination of Illegal Adding of Sibutramine Hydrochloride in Diet Pills of Traditional Chinese Medicine for Health Care

CAO Ling, ZHANG Yu-Lin, WANG Bao-Zhu

Jiangsu Institute for Drug Control, Nanjing 210008, China

Online:2008-02-15 Published:2011-08-24

摘要/Abstract

摘要： 建立减肥保健食品中非法添加化学成分盐酸西布曲明的定性、定量检测方法。采用薄层色谱法、高效液相色谱-二极管阵列检测法、LC/MS/MS联用技术进行定性鉴别,并采用高效液相色谱法测定其中盐酸西布曲明的含量。结果在抽取的43种市售产品中,有9种检出了盐酸西布曲明。该方法快速、简便、准确、可靠,可用于有效监测保健食品中非法添加的盐酸西布曲明。

关键词: 减肥保健食品, 盐酸西布曲明, 薄层色谱法, 高效液相色谱-二极管阵列检测法, LC/MS/MS联用

Abstract: To establish a method for identification and determination of illegal adding of chemical substance Sibutramine hydrochloride in the diet pills of traditional Chinese medicine for health care, TLC, HPLC-DAD and LC/MS/MS technology were employed to isolate and identify the Sibutramine hydrochloride. The content determination was made by HPLC. Among the 43 samples purchased from market, 9 samples contained Sibutramine hydrochloride. The method is specific, sensitive, convenient and the precision was satisfactory, and it can be used efficiently for control and surveillance of illegal adding of chemical substance Sibutramine hydrochloride in the diet pills of traditional chinese medicine for health care.

Key words: diet pills of traditional Chinese medicine for health care, Sibutramine hydrochloride, TLC, HPLC-DAD, LC/MS/MS

曹玲, 张妤琳, 王宝珠. 减肥保健食品中非法添加盐酸西布曲明的检测[J]. 食品科学, 2008, 29(2): 340-343.

CAO Ling, ZHANG Yu-Lin, WANG Bao-Zhu. Identification and Determination of Illegal Adding of Sibutramine Hydrochloride in Diet Pills of Traditional Chinese Medicine for Health Care[J]. FOOD SCIENCE, 2008, 29(2): 340-343.

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