食品科学 ›› 2005, Vol. 26 ›› Issue (12): 205-208.

• 营养卫生 • 上一篇    下一篇

食醋对催老小鼠抗氧化活性的影响

 徐清萍, 陶文沂, 敖宗华   

  1. 江南大学工业生物技术教育部重点实验室
  • 出版日期:2005-12-15 发布日期:2011-10-01

Antioxidation Effects of Vinegar on Ageing Accelerating Model Mice

 XU  Qing-Ping, TAO  Wen-Yi, AO  Zong-Hua   

  1. The Key Laboratory of Industrial Biotechnology, Ministry of Education, Southern Yangtze University
  • Online:2005-12-15 Published:2011-10-01

摘要: 目的:研究恒顺香醋对小鼠的抗氧化作用。方法:恒顺香醋浓缩为原体积的1/3,pH调至6~7,测定其中抗氧化活性成分总酚含量、总黄酮含量。小鼠分为5组,正常对照组和衰老模型对照组用生理盐水灌胃,给药组用浓缩醋分别以1.2、0.6、0.3g/kg•d的剂量灌胃,连续灌胃35d。测定小鼠血浆MDA含量,SOD、GSH-Px活性,以及肝指数、脾指数等指标。结果:1.2g/kg•d恒顺香醋组可显著降低血浆MDA水平,增强SOD、GSH-Px的活性,同时可显著抑制注射D-半乳糖引起小鼠肝指数的降低,对脾指数的降低也有一定的抑制作用。0.6g/kg•d香醋组可显著抑制注射D-半乳糖引起的GSH-Px/LPO比值的降低。结论:恒顺香醋对小鼠有一定的抗氧化作用。

关键词: 食醋, 抗氧化, 小鼠, D-半乳糖

Abstract: Objective: Antioxidation activities of vinegar in ageing-accelerating model mice were studied in this paper. Methods: Hengshun vinegar were concentrated to 13 of initial volume, and neutralized to pH6~7 or so. Amount of total phenolic compounds and total flavones in vinegar were determined. Mice (2 months age) were divided into five groups: ageing accelerating model and young control group, while the control group was gavage instilled normal saline. Vinegar groups were instilled 1.2, 0.6, 0.3gkg•d for 35 days respectively. MDA, SOD and GSH-Px of mice plasm were measured and liver index and spleen index were determined. Results: Hengshun vinegar (1.2gkg•d) could reduce the level of MDA, and increase the activities of SOD and GSH-Px. Hengshun vinegar may inhibit the reduction of liver index and spleen index. Hengshun aromatic vinegar (0.6gkg• d) might inhibit the reduction of GSH-PxLPO ratio caused by instilling D-galactose. Conclusion : Hengshun vinegar has shown antioxidation activities.

Key words: vinegar, antioxidation activity, mice, D-galactose