当归多糖对亚急性辐射损伤小鼠的防护作用研究

食品科学 ›› 2007, Vol. 28 ›› Issue (2): 305-308.

当归多糖对亚急性辐射损伤小鼠的防护作用研究

孙元琳, 顾小红, 李德远, 汤坚

运城学院生命科学系；江南大学测试中心；军事经济学院营养食品研究所；江南大学食品科学与安全教育部重点实验室山西运城044000 江南大学食品科学与安全教育部重点实验室；江苏无锡214036；湖北武汉430045；

出版日期:2007-02-15 发布日期:2011-12-31

Study on Radioprotection Effects of Angelica sinensis Polysaccharides on Sub-acute Radiation-injured Mouse

SUN Yuan-Lin, GU Xiao-Hong, LI De-Yuan, TANG Jian

1. Department of Life Sciences, Yuncheng University, Yuncheng 044000, China;2. Key Laboratory of Food Science and Safety, Ministry of Education, Southern Yangtze University, Wuxi 214036, China;3. Testing and Analysis Center, Southern Yangtze University , Wuxi 214036, China;4. Nutrition and Food Research Institute, Wuhan Economic College, Wuhan 430035, China

Online:2007-02-15 Published:2011-12-31

摘要/Abstract

摘要： 目的:考察当归多糖ASP3组分对亚急性辐射损伤小鼠的防护作用。方法:以当归多糖ASP3组分为受试物,用60Coγ射线对小鼠进行一次性全身照射,采用推片染色、试剂盒检测、MTT等方法检测外周血白细胞、淋巴细胞数量,骨髓嗜多染红细胞(PCE)微核率,淋巴细胞转化率,肝组织SOD活力、MDA含量。结果:ASP3对亚急性辐射损伤小鼠的外周血白细胞、淋巴细胞数量的回升均有明显的促进作用,并能有效地抑制PCE微核的形成,促进外周血淋巴细胞转化以及肝组织的抗氧化能力,增强机体的辐射耐受性。结论:当归多糖具有一定的抗辐射功能,对亚急性辐射损伤小鼠有良好的防护作用。

关键词: 当归多糖, 亚急性辐射, 辐射防护

Abstract: Objective: To investigate the radioprotective effect of Angelica sinensis polysaccharide ASP3 on sub-acute radiation- injured mice. Methods: Polysaccharide ASP3, prepared from Angelica sinensis, was orally administered to groups of mice. After being exposed wholely to 60Coγ-rays once, peripheral leucocyte and lymphocyte counts, micronuclei frequency of PCE in bone marrow, transformation rates of peripheral lymphocyte, SOD and MDA of liver cells were examined. Results: ASP3 could protect leucocytes and lymphocytes, prohibit formation of micronucleus of polychromatic erythrocytes in bone-marrow, speed trans- formation rate of peripheral lymphocytes, content of SOD of liver cells and enhance the radiation endurance of the body. Conclusion: ASP3 has radioprotective effects on sub-acute radiation-injured mice.

Key words: Angelica sinensis, sub-acute radiation, radioprotection

孙元琳, 顾小红, 李德远, 汤坚. 当归多糖对亚急性辐射损伤小鼠的防护作用研究[J]. 食品科学, 2007, 28(2): 305-308.

SUN Yuan-Lin, GU Xiao-Hong, LI De-Yuan, TANG Jian. Study on Radioprotection Effects of Angelica sinensis Polysaccharides on Sub-acute Radiation-injured Mouse[J]. FOOD SCIENCE, 2007, 28(2): 305-308.

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