食品科学 ›› 2000, Vol. 21 ›› Issue (6): 23-25.

• 基础研究 • 上一篇    下一篇

两歧双歧杆菌免疫原性的研究

 孙震, 张灏, 承拥军   

  1. 无锡轻工大学食品学院
  • 出版日期:2000-06-16 发布日期:2011-12-01

Studies on Immunogenicity of Bifidobacterium bifidum

 SUN  Zhen, ZHANG  Hao, CHENG  Yong-Jun   

  • Online:2000-06-16 Published:2011-12-01

摘要: 机体在大剂量、长时间的口服两歧双歧杆菌后才能在其血清中检出特异性抗体,而非正常寄居菌沙门氏菌则在经四摄取后很短时间内,产生较高水平的特异性抗体,并维持较长的时间。可以认为尽管摄入的双歧杆菌数量很大,一般不易引起宿主产生抗体,即使产生抗体也是低水平的,或在短时间内有一定的反应,之后很快便消失。进一步的研究表明,在体外诱导脾细胞的产生免疫应答的细胞数量上,双歧杆菌的数量是沙门氏菌的20倍。由此推论,两歧双歧杆菌经口服后具有较弱的免疫原性。

关键词: 两歧双歧杆菌, 免疫原性

Abstract: The mice were given oral administration of a large anount of Bifidobacteriun bifidim for a long time. Significant anounts of anti-B.bifidum antibody were detected in the serum.However, in mice administratd Salmonella sp.,the antibody were detected in much higher level in a short time.These results suggest that the enormus numbers B.bifidim were hard to induce serim antibody production. Even if some antibody was produced the level was rather low, and quickly decreased- Furthermore, in vitro test, the optimal dose of B.Bifidum used to induce antibody production by spleen lymphocyte was 20 times than that of Sal. sp. .Thus, the study showed that B.bifidum was a weakly immunogenic antigen.

Key words: Bifidobacterium bifidum Immunogenicity