食品科学 ›› 1999, Vol. 20 ›› Issue (8): 17-20.

• 基础研究 • 上一篇    下一篇

三磷酸肌醇清除自由基的作用

 余以刚, 姚惠源   

  1. 无锡轻工大学食品学院
  • 出版日期:1999-08-15 发布日期:2011-12-05

 YU  Yi-Gang, YAO  Hui-Yuan   

  • Online:1999-08-15 Published:2011-12-05

摘要: 采用电子自旋共振波谱仪检测了三磷酸肌醇(IP3)清除羟基自由基(·OH)和超氧阴离子自由基(O)的作用。结果表明:利用Fenton反应体系,酵母和植酸酶制备的IP3对基自由基(·OH)的清除率各达75.34%和73.29%,样品浓度分别为6mg/ml和9mg/ml;利用次黄嘌呤-黄嘌呤氧化酶体系,酵母和植酸酶制备的IP3对超氧阴离子自由基(O)的清除率达72.76%和53.84%,样品浓度分别为18mg/ml和9mg/ml。同时认为IP3之所以对多种疾病具有预防、减轻和治疗效果,主要是因为IP3具有比较强大的清除自由基的功能。

关键词: 三磷酸肌醇, 自由基, 清除

Abstract: Effecs of inositol triphosphate (IP3)on scavenging free radicals were identified by electron paramagnetic resonance (EPR)spectroscopy.In Fenton reaction system.the scavenging rate of (OH)by IP:(produced by baker’s yeast )In 6mg/ml was 75.34%. the scavenging rate of (OH)by IP3(produced by phytase) in 9mg/ml was 73.29%.In HX-OX reaction system .the scavenging rate of(O)by IP3(produced by baker’s yeast )in 18mg/ml was 72.76%.the scavenging rate of (O.2) by IP3(produced by phytase )in 9mg/ml was 53.84%. It was deduced that.thc reason why IP3 could be used as a curative for preventing alleviating or combating several diseases was that IP3 could scavenge free radicals efficiently.

Key words: Inositol, Triphosphate, Free radical, Scavenging