食品科学 ›› 1999, Vol. 20 ›› Issue (6): 25-29.

• 基础研究 • 上一篇    下一篇

生物活性肽─酪蛋白磷酸肽(CPPs)的研究、应用及展望

 庞广昌,  陈庆森   

  1. 天津商学院食品与生物工程系
  • 出版日期:1999-06-15 发布日期:2011-12-09

 PANG  Guang-Chang,   Chen-Qing-Sen   

  • Online:1999-06-15 Published:2011-12-09

摘要:  酪蛋白的基本功能是为生物体提供氨基酸和氨源。但是,人们似乎并没有注意到奶蛋白,尤其是酪蛋白,还是生物活性肽的主要来源。在离体和在体条件下,通过蛋白酶水解酪蛋白均得到一系列生物活性肽。这些活性肽按照其生物学作用有:促进营养吸收的,如:磷酸肽,类吗啡因子;饭后促激素分泌的,如:类吗啡因子;激活免疫活性的,如:免疫活性肽,酪激肽.类吗啡因子;以及神经性内分泌信号传递体,如:酪激肽。酪蛋白磷酸肽(CPPs)是可以促进钙质吸收的生物活性肽。已经发现CPPs不仅可以促进钙质吸收,还可以有效地促进锌、铁等的吸收,也可以防止蛀牙,可以用于牙膏、漱口液等。日本和德国已经把CPPs定为功能性食品。但是,到目前为止.中国在这方面只有很少的研究,所以该综述意在介绍CPPs研究的主要工作,并展望它的研究和应用前景。

关键词:  , 综述, 酪蛋白磷酸肽(CPPs), 应用, 生物活性肽

Abstract: The primary function of dietary protein is to supply the body adequately with amino acids and organicnitrogen. Up to now. little attention has been given to milk proteins. in particular casein, which is the main source ofbiologically active peptides. A series of bioactive peptides can be released by enzymatic proteolysis of casein invitro or in vivo. The regulatory effects concern nutrient uptake (phosphopeptides, casomorphins), postprandialhormone secretion (casomorphins). immune defense (immunopeptides, casokinins. casomorphins) and neuroendocrine information transtbr (casokinins). Casein phosphopeptides (CPPs) are the exclusive biological active peptidesthat can increase the absorption of calcium. CPPs have been found interesting applications as dietary supplementsand pharmaceutical preparations and toothpaste. mouthwash for their anticariogenicity. Japan and Germany governments had recommended CPPs for important functional food additives. UP to now. only a little works have beendone on researches and applications of CPPs in China. This review will introduce the main works on these aspectsfor CPPs certainly should be found widely uses in China.

Key words:  , Review Casein phosphopeptides (CPPs) Applications Bioactive peptides;