食品科学 ›› 2012, Vol. 33 ›› Issue (21): 359-362.

• 专题论述 • 上一篇    下一篇

姜黄素对谷胱甘肽代谢酶诱导及抗氧化机制研究进展

张婧菲,王 恬*   

  1. 南京农业大学动物科技学院
  • 收稿日期:2011-10-24 修回日期:2012-10-25 出版日期:2012-11-15 发布日期:2012-11-09
  • 通讯作者: 张婧菲 E-mail:zjf1516311@yahoo.cn

Research Progress in Induction of Glutathione Metabolic Enzymes by Curcumin and Its Antioxidant Mechanism

Jing-Fei ZHANG   

  • Received:2011-10-24 Revised:2012-10-25 Online:2012-11-15 Published:2012-11-09
  • Contact: Jing-Fei ZHANG E-mail:zjf1516311@yahoo.cn

摘要: 姜黄素(curcumin)作为一种天然食品香料和着色剂,已广泛应用于食品加工领域。近年来体内外实验表明,姜黄素除具有着色作用外,抗氧化功能也十分明显;这种抗氧化功能与细胞内的谷胱甘肽水平有关。本文综述姜黄素的抗氧化功能与机体内谷胱甘肽含量变化之间的联系,重点阐述姜黄素对谷胱甘肽相关代谢途径中关键酶的不同诱导作用,分析探讨姜黄素对谷胱甘肽代谢酶的诱导作用及其发挥体内抗氧化机制之间的关系。

关键词: 姜黄素, 抗氧化, 谷胱甘肽,

Abstract: Curcumin is a natural spice and coloring agent which has been widely used in the food processing industry. Recent studies in vitro have demonstrated that curcumin also has potent antioxidant activity, which is closely associated with  intracellular glutathione levels. This article reviews the antioxidant activity of curcumin and its association with intracellular glutathione levels. We focus on the induction of rate-limiting enzymes involved in glutathione metabolic pathways by curcumin.  Meanwhile, the inductive effect of curcumin on glutathione metabolic enzymes and its antioxidant mechanism are analyzed.

Key words: curcumin, antioxidant, glutathione, enzyme