矢车菊素-3-葡萄糖苷通过AMPK抑制成熟脂肪细胞脂蛋白脂酶活性

食品科学 ›› 2012, Vol. 33 ›› Issue (23): 305-309.

矢车菊素-3-葡萄糖苷通过AMPK抑制成熟脂肪细胞脂蛋白脂酶活性

卫晓怡1，白晨1,*，唐立伟1，陆红2，李浩1

1.上海商学院旅游与食品学院 2.复旦大学生命科学学院

收稿日期:2011-09-13 修回日期:2012-09-23 出版日期:2012-12-15 发布日期:2012-12-12
通讯作者: 白晨 E-mail:baichen@fudan.edu.cn
基金资助:
上海市教育委员会科研创新项目

Cyanidin-3-O-β-Glucoside Inhibits Lipoprotein Lipase Activity through Activating AMP-Activated Protein Kinase in Adipocytes

Received:2011-09-13 Revised:2012-09-23 Online:2012-12-15 Published:2012-12-12
Contact: Chen BAI E-mail:baichen@fudan.edu.cn

摘要/Abstract

摘要： 通过矢车菊素-3-葡萄糖苷(Cy-3-g)干预成熟脂肪细胞，研究Cy-3-g对细胞脂蛋白脂酶(LPL)活性的影响及其作用机制。结果表明： Cy-3-g通过激活一磷酸腺苷激活的蛋白激酶(AMPK)抑制成熟脂肪细胞的LPL活性，提示Cy-3-g具有潜在的调节机体脂代谢作用，与含Cy-3-g的花色苷提取物的肥胖抑制作用密切相关。

关键词: 矢车菊素-3-葡萄糖苷, 脂肪细胞, 脂蛋白脂酶, 一磷酸腺苷激活的蛋白激酶

Abstract: The major purpose of this study was to explore the effect of cyanidin-3-O-β-glucoside (Cy-3-g) on lipoprotein lipase(LPL) activity in adipocytes isolated from rats. It was found that Cy-3-g could inhibit LPL activity in adipocytes through activating pAMPK. This suggests that Cy-3-g may have a potential role against obesity through regulating lipid metabolism.

Key words: cyanidin-3-O-β-glucoside, adipocytes, lipoprotein lipase, AMP-activated protein kinase

中图分类号:

TQ936.16

卫晓怡1，白?晨1,*，唐立伟1，陆?红2，李?浩1. 矢车菊素-3-葡萄糖苷通过AMPK抑制成熟脂肪细胞脂蛋白脂酶活性[J]. 食品科学, 2012, 33(23): 305-309.

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