黑米花青苷复方胶囊对实验性肝损伤的保护作用

食品科学 ›› 2013, Vol. 34 ›› Issue (3): 261-263.

黑米花青苷复方胶囊对实验性肝损伤的保护作用

路宏朝¹,王杨科¹,李丽霞¹,张涛²,李新生²,王琦¹

1. 陕西理工学院生物科学与工程学院
2. 陕西理工学院

收稿日期:2011-11-11 修回日期:2013-01-09 出版日期:2013-02-15 发布日期:2017-12-29
通讯作者: 王琦 E-mail:wangqis6@163.com
基金资助:
陕西省教育厅重点实验室项目;陕西省发改委陕南突破发展项目;陕西省科技厅重点实验室专项研究计划项目

Protective Effect of Black Rice Anthocyanin Compound Capsule on Experimental Hepatic Injury

Received:2011-11-11 Revised:2013-01-09 Online:2013-02-15 Published:2017-12-29

摘要/Abstract

摘要： 要：建立小鼠四氯化碳（CCl4）肝损伤病理模型，分别灌胃低剂量、高剂量的黑米花青苷复方胶囊进行治疗，正常组灌胃蒸馏水，助悬剂组灌胃植物油。5wk后，测定肝组织中超氧化物歧化酶(SOD)活力、丙二醛(MDA)含量、谷胱甘肽(GSH)含量及肿瘤坏死因子-α(TNF-α)水平，并进行肝脏病理学观察。结果表明：黑米花青苷复方胶囊能明显提高肝组织中SOD的活力，对MDA起到直接清除作用；能提高GSH含量，降低TNF-α的水平；同时，能有效显著改善肝组织的纤维化。助悬剂对药物的效果基本没有影响。因此，黑米花青苷复方胶囊能够对CCl4肝损伤起到一定的防治作用。

Abstract: Abstract: Establishments pathology model of carbon tetrachloride (CCl4)–induced hepatic injury in mice and cured by poured the black rice anthocyanin compound capsule in low concentration and high concentration into stomach, distilled water for the normal group, and plant oil for the suspending agents group. The content of SOD, MDA, GSH and the levels of TNF-α in liver homogenate were measured after 5wk. Hepatic pathological examination was observed．The result show that the black rice anthocyanin compound capsule can increase SOD activity obviously, clear MDA content directly in hepatic tissue, improve GSH content and reduce TNF-α level. The pathology analysis suggested that black rice anthocyanin compound capsule improve hepatic fibrosis in mice. Suspension agents basically have no influence on drug effect. Therefore the black rice anthocyanin compound capsule has a particular treatment effect on CCl4 hepatic injury

中图分类号:

TS218

路宏朝王杨科李丽霞张涛李新生王琦. 黑米花青苷复方胶囊对实验性肝损伤的保护作用[J]. 食品科学, 2013, 34(3): 261-263.

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