黄芪多糖免疫调节作用研究进展

doi:10.7506/spkx1002-6630-201311069

摘要/Abstract

摘要：

黄芪是一味可药食两用的传统中药材，其中含量最多的活性成分为黄芪多糖。黄芪多糖是一种有多重功效的天然提取物质，具有调节血糖、保护肝肾、调节免疫力和抗氧化防衰老的功效，尤以免疫调节功能最为突出。本文综合该领域的有关研究成果，就免疫器官、免疫细胞以及有关细胞因子和基因表达等多个方面对黄芪多糖的免疫调节功能进行综述。

关键词: 黄芪多糖, 免疫调节, 作用机理

Abstract:

Astragalus is a traditional Chinese herbal that can be used as both medicine and therapy foods, and its most
active ingredient content is Astragalus polysaccharides. The natural extract substance, Astragalus polysaccharides, has
multiple effects including modulating blood glucose, protecting liver and kidney, adjusting immunity, preventing oxidation
and senimu. Among these functions, immunoregulation is the most outstanding one. In this paper, immunoregulation
function of Astragalus polysaccharides is studied from the aspects of immune organs, immune cells and the expression of
relevant cell factors and genes based on the synthesis of the relevant research results in this field.

Key words: Astragalus polysaccharide, immunoregulation, mechanism of action

中图分类号:

姜琛璐，汤承，骞宇，索化夷，李林. 黄芪多糖免疫调节作用研究进展[J]. 食品科学, 2013, 34(11): 327-332.

JIANG Chen-lu，TANG Cheng，QIANG Yu，SUO Hua-yi，LI Lin. Immunoregulation Effect of Astragalus Polysaccharides[J]. FOOD SCIENCE, 2013, 34(11): 327-332.

参考文献

[1]蔡亚平, 赵蕊, 朱丹.黄芪多糖的组成分析[J].中国实验方剂学杂志,2011,17(1):81-83
[2]刘星堦, 王美英, 吴厚生, 等.黄芪多糖的分离及其免疫活性的研究[J].天然产物研究与开发,1994,(6):23-31
[3]KAJIMURA Keiji, TAKAGI Yasuhiro, MIYANO Keiichi, et al.Polysaccharide of Astragali Radix enhance IgM antibody production in aged mice[J].Biological and Pharmaceutical Bulletin,1997,20(11):1178-1182
[4]LI Shigang, ZHANG Yongqi.Characterization and renal protective effect of a polysaccharide from Astragalus membranaceus[J].Carbohydrate Polymers,2009,78(2):343-348
[5]LI Rui, CHEN Weichang, WANG Weipeng, et al.Extraction, characterization of Astragalus polysaccharides and its immune modulating activities in rats with gastric cancer[J].Carbohydrate Polymers,2009,78(4):738-742
[6]李宏全, 赵万国, 吕小虎.动物免疫增效剂黄芪多糖化学组分及其结构分析[J].中兽医医药杂志,2008,(5):5-8
[7]JIANG Junbing, WU Ccaihong, GAO Hai, et al.Effects of Astragalus polysaccharides on immunologic function of erythrocyte in chickens infected with infectious bursa disease virus[J].Vaccine,2010,28(34):5614-5616
[8]YAN Hui, XIE Yupeng, SUN Shiguang, et al.Chemical analysis of Astragalus mongholicus polysaccharides and antioxidant activity of the polysaccharides[J].Carbohydrate Polymers,2010,82(3):636-640
[9]单俊杰, 王顺春, 刘涤, 等.黄芪多糖体的化学和药理研究进展[J].上海中医药大学学报,2000,14(3):62-65
[10]胡晓燕, 郝选明.黄芪多糖对运动性免疫抑制的调理[J].广州体育学院学报,2011,31(1):85-88
[11]安松兰, 张善玉孙, 朴惠顺.1年生黄芪中黄芪多糖对小鼠免疫器官指数的影响[J].延边大学医学学报,2007,30(1):195-197
[12]邱妍, 董发明, 胡元亮.黄芪多糖对新支二联疫苗免疫雏鸡的免疫调节作用[J].中国预防兽医学报,2011,33(3):232-235
[13]刘明研.黄芪多糖对犬免疫指标的影响[J].黑龙江畜牧兽医,2011,(7):142-144
[14]魏凤仙, 李绍钰, 孔祥书, 等.黄芪多糖对生长猪生产性能及免疫性能的影响[J].中国畜牧兽医,2006,33(10):17-19
[15]SHAO Baomei, XU Wen, DAI Hui, et al.A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus , a Chinese medicinal herb[J].Biochemical and Biophysical Research Communications,2004,320(4):1103-1111
[16]宋淑珍, 田亚平, 汪德清, 等.黄芪多糖对健康体检者淋巴细胞亚群的调节作用[J].中国临床康复,2005,9(11):130-131
[17]张守栋, 李明, 吕英然, 等.黄芪多糖的药理研究进展[J].畜牧兽医科技信息,2011,(2):10-12
[18]翁玲, 刘彦, 刘雪英, 等.黄芪多糖粉针剂对小鼠脾细胞分泌细胞因子及NK杀伤能力的影响[J].中医药学刊,2003,21(9):1522-1524
[19]LIU Qingyang, YAO Yongming, ZHANG Shuwen, et al.Astragalus polysaccharides regulate T cell-mediated immunity via CD11chigh CD45RBlow DCs in vitro[J].Journal of Ethnopharmacology,2011,136(3):457-464
[20]SUN Yongxin, JIN Liji, WANG Tingting, et al.Polysaccharides from Astragalus membranaceus promote phagocytosis and superoxide anion (O2?) production by coelomocytes from sea cucumber Apostichopus japonicus in vitro[J].Comparative Biochemistry and Physiology,2008,147(3):293-298
[21]王旭贞, 李宏全, 孙杰.黄芪多糖对接种NDIV雏鸡红细胞免疫功能的影响[J].农业技术与装备,2011,(4):58-61
[22]LI Hongquan, LLOYD Reevejohnson, WANG Jundong.Effect of Astragalus polysaccharides on erythrocyte immune adherence of chickens inoculated with infectious Bursa1 Disease virus[J].Agricultural Sciences in China,2007,6(11):1402-1408
[23]陈朝俊, 李志梁, 傅强, 等.黄芪多糖对人单核细胞源性的树突状细胞成熟和免疫功能的影响[J].中华老年心脑血管病杂志,2009,11(11):879-881
[24]SHAO Peng, ZHAO Luhang, CHEN Zhi, et al.Regulation on maturation and function of dendritic cells by Astragalus mongholicus polysaccharides[J].International Immunopharmacology,2006,6(7):1161-1166
[25]黄小英, 刘端勇, 赵海梅.黄芪多糖免疫调节作用研究进展[J].江西中医学院学报,2008,20(4):75-77
[26]李杰峰, 张挪威, 刘发强, 等.黄芪多糖对疫苗免疫的调节作用机理[J].兽医导刊,2011,(2):48-49
[27]陈蔚, 李益明, 俞茂华, 等.黄芪多糖对糖尿病鼠T细胞亚群的免疫调节作用[J].中国现代医学杂志,2007,17(1):28-31
[28]YIN Xiaolin, CHEN Lei, LIU Ying, et al.Enhancement of the innate immune response of bladder epithelial cells by Astragalus polysaccharides through upregulation of TLR4 expression[J].Biochemical and Biophysical Research Communications,2010,397(2):232-238
[29]Zhao Luhang, MA Zhixin, ZHU Jie, et al.Characterization of polysaccharide from Astragalus radix as the macrophage stimulator[J].Cellular Immunology,2011,271(2):329-334
[30]徐荔, 何小鹃, 柴旺, 等.黄芪多糖对内毒素诱导巨噬细胞产生TNF-α、IL-1β及NO的影响[J].中国中医基础医学杂志,2011,17(5):503-504
[31]JOSHUA Kashunko, CECILIA Waishanchik.The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines[J].Cytokine,2009,47(2):85-90
[32]樊英, 王淑娴, 叶海斌, 等.黄芪多糖对仿刺参非特异性免疫功能的影响[J].水产科学,2010,29(6):321-324
[33]胡庭俊, 程富胜, 陈炅然, 等.黄芪多糖对小鼠免疫细胞信号转导相关分子的影响[J].畜牧兽医学报,2005,36(6):616-619
[34]张伟妮, 林旋, 王寿昆, 等.黄芪多糖对罗非鱼非特异性免疫和胃肠内分泌功能的影响[J].动物营养学报,2010,22(2):401-409
[35]Li Jiefeng, ZHONG Yougang, LI Huanrong, et al.Enhancement of Astragalus polysaccharide on the immune responses in pigs inoculated with foot-and-mouth disease virus vaccine[J].International Journal of Biological Macromolecules,2011,49(3):362-368
[36]YUAN Chuntao, PAN Xuping, GONG Yi, et al.Effects of Astragalus polysaccharides (APS) on the expression of immune response genes in head kidney, gill and spleen of the common carp, Cyprinus carpio L[J].. International Immunopharmacology,2008,(8):51-58
[37]朱培成, 榻国维, 陈达灿, 等.黄芪多糖对斑秃患者PBMC中Thl／Th2型细胞因子、转录因子T-bet mRNA表达的调节作用[J].广东医学,2007,28(10):1685-1687
[38]LEE Youngsun, HAN Okkyung, PARK Chanwoo, et al.Pro-inflammatory cytokine gene expression and nitric oxide regulation of aqueous extracted Astragali radix in RAW 2647 macrophage cells[J].. Journal of Ethnopharmacology,2005,100(3):289-294
[39]LEE Kunyeong, JEON Youngjin.Macrophage activation by polysaccharide isolated from Astragalus membranaceus[J].International Immunopharmacology,2005,5(7-8):1225-1233
[40]肖啸, 张开伟, 沈学文, 等.黄芪多糖对犬免疫指标的影响[J].山东畜牧兽医,2009,30:3-5
[41]李巨银.黄芪多糖对雏鸡传染性法氏囊病预防效果的研究[J].广东饲料,2011,20(2):20-22
[42]LI Rui, CHEN Wwechang, WANG Weipeng, et al.Antioxidant activity of Astragalus polysaccharides and antitumour activity of the polysaccharides and siRNA[J].Carbohydrate Polymers,2010,82(2):240-244
[43]YAN Hui, XIE Yupeng, SUN Shiguang, et al.Chemical analysis of Astragalus mongholicus polysaccharides and antioxidant activity of the polysaccharides[J].Carbohydrate Polymers,2010,82(3):636-640
[44]ZHANG Xianjun, CHEN Gengzhen, KE Mang, et al.A study onAstragalus mongholicus heterosaccharides affecting contractions of isolated bladder detrusor strips[J].Carbohydrate Polymers,2011,85(2):312-317
[45]WILLIAM Chishingcho, KWOK Namleung.In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus[J].Journal of Ethnopharmacology,2007,113(1):132-141
[46]MA Xia, GUO Zhenhuan, WANG Deyun, et al.Effects of sulfated polysaccharides and their prescriptions on immune response of ND vaccine in chicken[J].Carbohydrate Polymers,2010,82(1):9-13
[47]WANG Junmin, HU Yuanliang, WANG Deyun, et al.Sulfated modification can enhance the immune-enhancing activity of lyceum barbarum polysaccharides[J].Cellular Immunology,2010,263(2):219-223
[48]ZHAO Xiaona, HU Yuanliang, WANG Deyun, et al.Optimization of sulfated modification conditions of tremella polysaccharide and effects of modifiers on cellular infectivity of NDV[J].International Journal of Biological Macromolecules,2011,49(1):44-49
[49]GUO Zhenhuan, HU Yuanliag, WANG Deyun, et al.Sulfated modification can enhance the adjuvanticity of lentinan and improve the immune effect of ND vaccine[J].Vaccine,2009,27(5):660-665
[50]黄小燕, 胡元亮, 卢宇, 等.正交实验优选黄芪多糖硫酸化修饰条件及修饰产物抗IBDV活性测定[J].中药材,2008,31(4):588-592
[51]HUANG Xiaoyan, HU Yuanliang, ZHAO Xiaona, et al.Sulfated modification can enhance the adjuvant activity of Astragalus polysaccharide for ND vaccine[J].Carbohydrate Polymers,2008,73(2):303-308
[52]HUANG Xiaoyan, WANG Deyun, HU Yuangliang, et al.Effect of sulfated astragalus polysaccharide on cellular infectivity of infectious bursal disease virus[J].International Journal of Biological Macromolecules,2008,42(2):166-171
[53]施志玉, 黄小燕, 李大鹏, 等.硫酸化黄芪多糖对IBD疫苗接种雏鸡免疫水平的影响[J].畜牧与兽医,2009,41(2):6-8
[54]龚晓钟, 欧阳政.硒化黄茂多糖制备条件及其结构的研究[J].天然产物研究与开发,1997,10(2):26-32
[55]龚晓钟.硒化黄芪多糖与硒化葡聚糖的研究——硒化条件选择[J].深圳大学学报,1997,14(14):68-75
[56]邓毅, 尹龙萍, 赵爱华, 等.黄芪多糖铬络合物的合成及其降血糖活性的初步研究[J].食品科学,2007,28(6):317-320
[57]张善玉, 朴惠顺, 申英爱.黄芪多糖与人参总皂苷联用的免疫调节作用初步研究[J].中国药房,2005,16(21):1620-1622
[58]YAN Fei, ZHANG Qiaoyan, JIAO Lei, et al.Synergistic hepatoprotective effect of Schisandraelignans with Astragalus polysaccharides on chronic liver injury in rats[J].Phytomedicine,2009,16(9):805-813
[59]FAN Yunpeng, HU Yuanliang, WANG Deyun, et al.Effects of Astragalus polysaccharide liposome on lymphocyte proliferation in vitro and adjuvanticity in vivo[J].Carbohydrate Polymers,2012,88(1):68-74
[60]王学斌, 陈功义, 魏战勇, 等.黄芪多糖粉剂和注射剂对雏鸡免疫功能和生长的影响比较[J].中国家禽,2007,29(3):21-23
[61]ZHANG Nuowei, LI Jiefeng, HU Yanxin, et al.Effects of astragalus polysaccharide on the immune response to foot-and-mouth disease vaccine in mice[J].Carbohydrate Polymers,2010,82(3):680-686
[62]HIROAKI Kiyohara, TAICHI Uchida, MANAMI Takakiwa, et al.Different contributions of side-chains in β- D-(1→3,6)-galactans on intestinal Peyer’s patch-immunomodulation by polysaccharides from Astragalus mongholics Bunge[J].Phytochemistry,2010,71(2-3):280-293
[63]张恩户, 王瑞昙, 岳明.不同分子量的黄苗多糖对免疫低下小鼠淋巴细胞转化和血清溶血素的影响[J].陕西中医学院学报,2010,33(3):75-76
[64]宋泽庆, 林璘, 朱艳芬.黄芪多糖对哮喘小鼠特异性免疫治疗的增强作用[J].中国免疫学杂志,2010,(26):132-135
[65]张竞之, 陈利国, 胡小勤, 等.不同分子量的黄苗多糖对免疫低下小鼠淋巴细胞转化和血清溶血素的影响[J].山东大学学报(医学版,2010,48(12):120-123
[66]昭日格图, 娜日苏, 博日吉汗格日勒图, 等.黄芪多糖咀嚼片降血脂人体试食试验研究[J].食品科学,2009,30(15):196-199
[67]李豪侠.黄芪多糖对老年胰腺癌晚期患者生存质量、细胞免疫功能的影响[J].中国中医药科技,2010,17(3):243-244
[68]陈增边.注射用黄芪多糖对鼻咽癌放射治疗患者免疫功能的影响[J].临床医学,2010,30(5):23-24
[69]吕兴萍.黄芪多糖在动物生产中的应用[J].上海畜牧兽医通讯,2011,(6):40-41