食品科学 ›› 2013, Vol. 34 ›› Issue (3): 115-118.

• 基础研究 • 上一篇    下一篇

青藤碱-γ-环糊精包合物的性质及谱学分析

朱士龙   

  1. 吉首大学化学化工学院
  • 收稿日期:2011-12-08 修回日期:2012-12-23 出版日期:2013-02-15 发布日期:2017-12-29
  • 通讯作者: 朱士龙 E-mail:elicss@163.com
  • 基金资助:
    湖南省自然科学基金资助项目;民族药用植物资源研究与利用湖南省重点实验室开放基金项目

Property and Spectral analysis On Inclusion Complex of Sinomenine to γ-Cyclodextrin

elicss   

  • Received:2011-12-08 Revised:2012-12-23 Online:2013-02-15 Published:2017-12-29
  • Contact: elicss E-mail:elicss@163.com

摘要: 摘 要:通过溶液共混法制备青藤碱-γ-环糊精包合物;纯化后利用体视显微镜观察包合物的结晶形态,通过差热示重扫描、红外光谱、X射线粉末衍射及核磁共振等方式对包合物进行分析鉴定和性质表征。实验结果证明青藤碱-γ-环糊精的包合物表现出明显不同于青藤碱的性质特征,青藤碱与γ-环糊精能形成稳定的新型包合物,γ-环糊精能显著增加青藤碱的溶解度,青藤碱与γ-环糊精形成的包合物的包合分子比为1∶1,其包合常数为600.3 L/mol,反应前后的吉布斯自由能变化为ΔG = -15.85KJ/mol。

Abstract: Abstract: The inclusion complex of SN with γ-CD was prepared successfully through mixed solution method, then the crystalline morphology and micromorphology of the inclusion complex was characterized and analyzed by stereomicroscope after purification and recrystallization. Other material behaviors of the inclusion complex of SN with γ-CD were characterized through X-ray diffraction(XRD), infrared spectrography(IR), differential scanning caborimetry(DSC) and hydrogen nuclear magnetic resonance(HNMR). The results present that the inclusion complex of SN with γ-CD show obvious characteristics compare to SN. The inclusion complex of SN with γ-CD was new material form, and γ-CD can sharply increase the solubility of SN, The molecular ratio of SN to γ-CD was 1:1, the inclusion constant was calculated as 600.3 L/mol and the Gibbs free energy of the complexation was -15.85KJ/mol.

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