食品科学 ›› 2012, Vol. 33 ›› Issue (15): 331-334.

• 专题论述 • 上一篇    下一篇

食品中亲电物质的最新研究进展

李 磊1,周昇昇2   

  1. 1.河南商业高等专科学校食品系 2.河南省疾病预防控制中心, 公共卫生研究所
  • 收稿日期:2011-06-27 修回日期:2012-05-28 出版日期:2012-08-15 发布日期:2012-09-07
  • 通讯作者: 李磊 E-mail:hongyi66@163.com

Research Progress in Electrophiles in Foods

  • Received:2011-06-27 Revised:2012-05-28 Online:2012-08-15 Published:2012-09-07
  • Contact: lei li E-mail:hongyi66@163.com

摘要: 食品中的亲电物质是高效低毒的核转录因子NF-E2相关因子2(Nrf2)诱导剂,通过Keap1/Nrf2/ARE通路激活Ⅱ相酶和抗氧化酶的转录。Ⅱ相酶和抗氧化蛋白可发挥慢速、长效的抗氧化和解毒作用。目前已经发现食品中有9类亲电物质,它们具有相似的结构特征。研究和开发食品中的亲电物质,将成为功能性食品新的研究领域。

关键词: 食品中的亲电物质, 基因营养学, 功能性食品, Ⅱ相酶

Abstract: Electrophiles in foods are efficient and low toxic inducer of the nuclear transcription factor NF-E2 related factor 2 (Nrf2), which activates the expression of phase Ⅱ detoxification enzymes and antioxidant enzymes through Keap1/Nrf2/ARE signaling pathway. The phase Ⅱ detoxification enzymes and antioxidant proteins play a slow, but long-lasting antioxidant and detoxification role in the body. So far, nine types of electrophiles have been identified in foods. They have similar structure. For their healthy property, it is believed that study of electrophiles in foods will be a new and hot research area of functional food.

Key words: electrophiles in foods, nutrigenetics, functional food, phaseⅡenzymes

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