[1] WAL J M. Structure and function of milk allergens[J]. Allergy, 2001, 56 Suppl, 67: 35-38.[2] WANG J, SAMSPON H A. Food allergy: recent advances in pathophysiology and treatment[J]. 2009, 1(1): 19-29.[3] POURPAK Z, MOSTSAFAIE A, HASAN Z, et al. A laboratory method for purification of major cow’s milk allergens[J]. J Immunoassay Immunochem, 2005, 25(4): 385-397.[4] 布冠好. 牛乳乳清蛋白过敏原调控技术及其机理研究[D]. 北京: 中国农业大学, 2009.[5] WAL J M. Cow’s milk allergens [J]. Allergy, 1998, 53: 1013-1022.[6] SASTRE J. Molecular diagnosis in allergy[J]. Clinical & Experimental Allergy, 2010, 40(10): 1442-1460.[7] 郭鸰, 霍贵成, 张英华. 牛乳蛋白过敏综述[J]. 食品科技, 2007, (4): 262-268.[8] 郑俊彦, 张昊, 郭慧媛, 等. 利用蛋白质改性技术降低牛乳致敏性的研究[J]. 中国乳业, 2011, (120): 46-49.[9] FRISCHé R, ADEL-PATEINT K, BERNARD H. IgE-mediated rat mast cell triggering with tryptic and synthetic peptides of bovine β-lactoglobulin[J]. Int Arch Allergy Immunol, 2005, 138(4): 291-297. [10] 布冠好, 郑枯, 郑海, 等. 牛乳过敏原β-乳球蛋白间接竞争ELISA检测方法的建立[J]. 中国农业大学学报, 2008, 13(6): 71-76.[11] 王红梅, 张永忠. 牛乳清β-乳球蛋白过敏原非酶改性技术研究进展[J]. 中国乳品工业, 2007, 35(6): 48-53.[12] MAYNARD F, JOST R. WAL J M. Human IgE binding capacity of tryptic peptides from bovine α-lactalbumin[J]. Int Arch Allergy Immunol, 1997, 113(4): 478-488.[13] FARRELL J H M, JIMENEZ-FLORES R, BLECK G T, et a1. Nomenclature of the proteins of cows’milk sixth revision[J]. Journal of dairy science, 2004, (6): 1641-1674.[14] 李欣, 陈红兵. 过敏原在食品加工中的变化[J]. 食品工业, 2005, 26(1): 50-52.[15] 王莹, 张丽萍. 胃蛋白酶分离纯化技术研究进展[J]. 中国食品添加剂, 2008, (1): 110-113.[16] 程伟, 陈红兵, 高金燕, 等. 酶改性技术对食物蛋白过敏性的影响[J]. 食品科学, 2010, 31(23): 391-394.[17] SCHMIDT D G., MEIJER R J, SLANGEN C J, et al. Raising the pH of the pepsin-catalyzed hydrolysis of bovine whey proteins increases the antigenicity of the hydrolysates[J]. Clin Exp Allergy, 1995, 25 (10), 1007–1017.[18] DUCHATEAU J, MICHIL A, LAMBERT J, et al. Anti-beta-lactoglobulin IgG antibodies bind to a speci?c pro?le of epitopes when patients are allergic to cow’s milk proteins[J]. Clin Exp Allergy, 1998, 28(7), 824-833.[19] HUSSEIN S, GELENCSER é, POLGáR M, et al. Effect of enzymatic modification on the biological activity and nutritive value of cow and buffalo casein[J]. Acta Alimentaria, 2000, 29(3): 273-288.[20] 唐宁, 刘保林, 汪福源, 等. 牛奶大分子蛋白的水解及其抗原性变化[J]. 中国临床药理学与治疗学, 2004, 9(12): 1398-1402.[21] KANANEN A, SAVOLAINEN J, M?KINEN J, et al. Influence of chemical modification of whey protein conformation on hydrolysis with pepsin and trypsin[J]. International Dairy Journal, 2000, 10(10): 691-697.[22] CHICóN R, LóPEZ-FANDI?O R, ALONSO E, el at. Proteolytic pattern, antigenicity and serum immunoglobulin E binding of β-lactoglobulin hydrolysates obtained by pepsin and high-pressure treatment[J]. Journal of Dairy Science, 2008, 91(3): 928-938.[23] 张颖, 罗永康, 张岩春. 发酵和酶解结合对乳清蛋白抗原性影响的研究[J]. 乳业科学与技术, 2010, (4): 151-155.[24] 张艺川. 糜蛋白酶临床应用进展[J]. 亚太传统医药, 2007, 3(7): 94-96.[25] 许小红, 高秀蓉, 许多光, 等. 糜蛋白酶效价测定[J]. 成都医学院学报, 2006, 1(2): 123-124.[26] ASSELIN J, AMIOT J, GAUTHIER S F. Immunogenicity and allergenicity of whey protein hydrolysates[J]. Journal of Food Science, 1988, 53(4): 1208-1211.[27] CHICóN R, BELLOQUE J, ALONSO E, et al. Antibody binding and functional properties of whey protein hydrolysates obtained under high pressure[J]. Food Hydrocolloids, 2009, 23(3): 593-599.[28] 郑海, 沈小琴, 布冠好, 等. 碱性蛋白酶水解乳清蛋白过敏原条件的优化[J]. 中国乳品工业, 2007, 35(4): 4-9.[29] WRóBLEWSKA B, JEDRYCHOWSKI L, SZABó E, et al. The reduction of cow milk proteins immunoreactivity by two-step enzymatic hydrolysis[J]. Acta Alimentaria, 2005, 34(3): 307-315.[30] 沈小琴, 郑海, 罗永康, 等. 酶解对乳清蛋白抗原性影响的研究[J]. 中国乳品工业, 2006, 34(6): 12-15.[31] WRóBLEWSKA B, TROSZY?SKA A. Enzymatic hydrolysis of cow’s whey milk proteins in the aspect of their utilization for the production of hypoallergenic formulas[J]. Polish Journal of Food and Nutrition Sciences, 2005, 14(4): 349-357.[32] WRóBLEWSKA B, JEDRYCHOWSKI L, HAJóS G, et al. Influence of Alcalase and Transglutaminase on immunoreactivity of cow milk whey proteins[J]. Czech J Food Sci, 2008, 26(1): 15-23.[33] ZHENG Hai, SHEN Xiaoqin, BU Guanhao, et al. Effects of pH, temperature and enzyme-to-substrate ratio on the antigenicity of whey protein hydrolysates prepared by Alcalase[J]. International Dairy Journal, 2008, 18(10): 1028-1033.[34] 张黎明, 袁永俊, 徐梦虬. 固定化胰蛋白酶的制备研究[J]. 食品与发酵科技, 2009, 45(2): 18-21.[35] SéLO I, CLéMENT G, BERNARD H, et al. Allergy to bovine β-lactoglobulin: speci?city of human IgE to tryptic peptides[J]. Clin Exp Allergy, 1999, 29(8): 1055–1063.[36] JU H R, OKUMIYA M, NISHIZONO S, et al. Increase in degranulation of mucosal mast cells in rats sensitized with milk whey protein hydrolysates compared with native proteins[J]. Food and Chemical Toxicology, 1997, 35(7): 663-668.[37] BERNARD H, NEGRONI L, CHATEL J M, et al. Molecular basis of IgE cross-reactivity between human β-casein and bovine β-casein, a major allergen of milk[J]. Molecular Immunology, 2000, 37(3): 161-167.[38] LAMETTI S, RASMUSSEN P, FR?KI?R H, et al. Proteolysis of bovine β-lactoglobulin during thermal treatment in subdenaturing conditions highlights some structural features of the temperature-modified protein and yields fragments with low immunoreactivity[J]. Eur J Biochem, 2002, 269(5): 1362-1372.[39] DUAN Cuicui, HUO Guicheng, YANG Lijie, et al. Comparison of sensitization between β-lactoglobulin and its hydrolysates[J]. Asian Pac J Allergy Immunol, 2012, 30(1): 32-39.[40] AZARKAN M, MOUSSAOUI A E, WUYTSWINKE D V, et al. Fractionation and purification of the enzymes stored in the latex of Carica papaya[J]. Journal of Chromatography B, 2003, 790(1): 229-238.[41] NORTH M J, MOTTRAM J C, COOMBS G H. Cysteine proteinases of parasitic protozoa[J]. Parasitology Today, 1990, 6(8): 270-275.[42] NAKAMURA T, SADO H, SYUKUNOBE Y, et al. Antigenicity of whey protein hydrolysates prepared by combination of two proteases[J]. Milchwissenschaft, 1993, 48(12): 667-670.[43] 白振宇, 庞广昌, 刘瑞玲, 等. 利用牛奶过敏者血清检验牛奶中过敏原酶解程度的研究[J]. 食品科学, 2006, 27(12): 46-49.[44] PRAKASH E S S, PUSHPA B P, JAYAPRAKASHA H M, et a1. Effect of enzymatic hydrolysis on antigenicity(allergenicity) of casein fractions of cow and buffalo milk[J]. Journal of Food Science and Technology, 2004, (4): 390-393.[45] LAKSHMAN P L N, TOYOKAWA Y, TACHIBANA S, et al. Reducing the antigenicity of milk whey protein using acid proteinases from Monascus pilosus[J]. Process Biochemistry, 2011, 46 (3): 806-810.[46] LAKSHMAN P L N, TACHIBANA S, TOYAMA H, et al. Application of an acid proteinase from Monascus purpureus to reduce antigenicity of bovine milk whey protein[J]. J Ind Microbiol Biotechnol, 2011, 38 (9): 1485-1492.[47] MONACI L, TREGOAT V, ARJON J, et al. Milk allergens, their characteristics and their detection in food: A review[J]. Eur Food Res Technol, 2006, 223(2): 149-179.[48] KIM S B, KI K S, KHAN M A, et al. Peptic and tryptic hydrolysis of native and heated whey protein to reduce its antigenicity[J]. J Dairy Sci 2007, 90(9): 4043-4050.[49] 刘晓宇, 李铮, 张颖, 等. 酶解对牛乳酪蛋白抗原性的影响[J]. 中国乳品工业, 2011, 39(2): 27-30.[50] KILARA A, PANYAM D. Peptides from milk proteins and their properties[J]. Crit Rev Food Sci Nutr, 2003, 43(6): 607-633.[51] WRóBLEWSKA B, JEDRYCHOWSKI L, FARJAN M. The allergenicity of a low molecular fraction of cow milk protein hydrolysates[J]. Milchwissenschaft, 2007, 62(4): 375-379.[52] PE?AS E, SNEL H, FLORIS R, et al. High pressure can reduce the antigenicity of bovine whey protein hydrolysates[J]. International Dairy Journal, 2006, 16(9): 969-975.[53] PRIOULT G, PECQUET S, FLISS I, et al. Allergenicity of acidic peptides from bovine β-lactoglobulin is reduced by hydrolysis with Bifidobacterium lactis NCC362 enzymes[J]. International Dairy Journal, 2005, 15(5): 439-448.[54] 周利亘, 陈新峰, 王君虹, 等. 乳源酪蛋白肤脱色工艺条件的研究[J]. 浙江农业学报, 2007, 19(2): 75-79.[55] HEFLE S L. Impact of processing on food allergens[J]. Adv Exp Med Biol, 1999, 459: 107-119. |