益生菌与肠上皮细胞间相互作用和免疫调节机制研究进展

doi:10.7506/spkx1002-6630-201321077

食品科学 ›› 2013, Vol. 34 ›› Issue (21): 394-398.doi: 10.7506/spkx1002-6630-201321077

益生菌与肠上皮细胞间相互作用和免疫调节机制研究进展

孟菲，王春凤，杨桂连*

吉林农业大学动物科学技术学院，吉林省动物微生态制剂工程研究中心，吉林长春 130118

收稿日期:2012-12-08 修回日期:2013-09-24 出版日期:2013-11-15 发布日期:2013-10-28
通讯作者: 杨桂连 E-mail:yangguilian@jlau.edu.cn
基金资助:
国家“863”计划项目(2011AA10A215；2013AA100806)；国家自然科学基金项目(31272552；31272541；81170358)；
教育部新世纪优秀人才支持计划项目(NCET-10-0175)；吉林省科技发展计划项目(20111816；20080104；201101112)；
吉林省世行贷款农产品质量安全项目(2011-Y07)；吉林省教育厅“十二五”科学技术研究项目(201149)

Mechanisms of Interaction between Probiotics and Intestinal Epithelial Cells and Immune Regulation

MENG Fei，WANG Chun-feng，YANG Gui-lian*

Jilin Provincial Engineering Research Center of Animal Probiotics, College of Animal Science and Technology,
Jilin Agricultural University, Changchun 130118，China

Received:2012-12-08 Revised:2013-09-24 Online:2013-11-15 Published:2013-10-28
Contact: YANG Gui-lian E-mail:yangguilian@jlau.edu.cn

摘要/Abstract

摘要：

定殖于肠道的益生菌能够通过调节上皮细胞中的信号途径如NF-κB和MAPK等来上调或抑制下游途径，从而改变胃肠道的生理机能，改善胃肠道微环境，因而常被用于预防或治疗多种疾病，但其作用机制目前尚未完全阐明。本文将从益生菌调节上皮细胞炎症信号通路、刺激产生热激蛋白以及调节细胞凋亡等方面入手，对益生菌与肠道上皮细胞间相互作用机制作以简单论述。

关键词: 益生菌, 肠上皮细胞, 信号通路, 作用机制

Abstract:

Probiotic colonization in the intestine by regulating signaling pathways such as NF-κB and MAPK to increase
or inhibit downstream pathways can change the physiology of the gastrointestinal tract, improve the micro-environment of
the gastrointestinal tract, and prevent and treat a variety of diseases, but its mechanism has not been fully understood. In this
article, the evidence about interaction between probiotics and intestinal epithelial cells, especially the emphasis on its regulation
of inflammatory signal pathways, stimulation of heat shock proteins, as well as the regulation of cell apoptosis, have
been reviewed, which will provide new theoretical basis for the diagnosis and treatment of intestinal diseases.

Key words: probiotics, intestinal epithelial cell, signal pathway, mechanism

中图分类号:

TS201

孟菲，王春凤，杨桂连*. 益生菌与肠上皮细胞间相互作用和免疫调节机制研究进展[J]. 食品科学, 2013, 34(21): 394-398.

MENG Fei，WANG Chun-feng，YANG Gui-lian*. Mechanisms of Interaction between Probiotics and Intestinal Epithelial Cells and Immune Regulation[J]. FOOD SCIENCE, 2013, 34(21): 394-398.

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益生菌与肠上皮细胞间相互作用和免疫调节机制研究进展

Mechanisms of Interaction between Probiotics and Intestinal Epithelial Cells and Immune Regulation

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