食品科学

• 营养卫生 • 上一篇    下一篇

海蜇糖蛋白及其糖肽的体外免疫活性

任国艳,刘志龙,郭金英,樊金玲,梁旺春,邵 征,康怀彬   

  1. 河南科技大学食品与生物工程学院,河南 洛阳 471003
  • 出版日期:2013-09-15 发布日期:2013-09-27
  • 通讯作者: 任国艳
  • 基金资助:

    国家自然科学基金项目(31000765);河南科技大学青年基金项目(2010QN0001)

Effects of Glycoprotein and Glycopeptides from Jellyfish on Immune Function of Mice in vitro

REN Guo-yan,LIU Zhi-long,GUO Jin-ying,FAN Jin-ling,LIANG Wang-chun,SHAO Zheng,KANG Huai-bin   

  1. College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471003, China
  • Online:2013-09-15 Published:2013-09-27
  • Contact: REN Guo-yan

摘要:

研究海蜇糖蛋白及其糖肽体外免疫活性。通过小鼠脾淋巴细胞增殖和转化实验,比较海蜇糖蛋白及其糖肽在不同培养时间、不同质量浓度条件下对小鼠体外免疫的影响。结果显示:不同培养时间、不同质量浓度的海蜇糖蛋白及糖肽均能不同程度地提高小鼠脾淋巴细胞的增殖和转化能力,且表现出一定剂量关系。糖肽Ⅰ组在提高小鼠脾淋巴细胞的增殖和转化能力方面显著优于其他几个组分,当糖肽Ⅰ组质量浓度为50μg/mL,培养60h对脾淋巴细胞的增殖和转化作用最强。

关键词: 海蜇, 糖蛋白, 糖肽, 体外免疫

Abstract:

The immunoregulatory activity of glycoprotein and glycopeptides from jellyfish was explored through cell
proliferation and cell transformation of mouse spleen lymphocytes and comparatively evaluated under various cultivation
times and concentrations. Jellyfish glycoprotein and glycopeptides revealed significant increase in the proliferation and
transformation of spleen lymphocytes in a dose-dependent manner. The results demonstrated that glycopeptides had
better immunoregulatory activity in vitro when spleen lymphocytes were cultivated for 60 hours and the concentration of
glycopeptides was 50 μg/mL.

Key words: jellyfish, glycoprotein, glycopeptides, immunomodulation in vitro

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