关键词: 反式脂肪酸, 膳食纤维, 小鼠, 胰岛素抵抗, 高脂血症

Abstract:

Objective: This study aimed to evaluate the effects of dietary fiber from corn husk on trans fatty acids-induced
insulin resistance in mice. Methods: The mouse model of hyperlipidemia was established by feeding with a diet with trans
fatty acids. Different groups of mice were given water-soluble dietary fiber, water-insoluble dietary fiber alone or their
combination with an SDF to IDF of ratio of 1:3 (m/m) at low, moderate and high doses. Results: The intake of trans fatty
acids significantly elevated fasting blood glucose, fasting serum insulin, homeostasis model assessment-insulin resistance
significantly (P ＜ 0.01), and reduced insulin sensitivity index, islet β-cell function and total superoxide dismutase (T-SOD)
significantly (P ＜ 0.01). Dietary fiber from corn husk significantly reduced fasting blood glucose and insulin resistance
(P ＜ 0.01), and significantly elevated insulin sensitivity index and islet β-cell function (P ＜ 0.01). Compared with those in
the hyperlipidemia model group, these parameters in mice fed with high dose of SDF:IDF changed significantly (P ＜ 0.01).
Conclusions: Trans fatty acids can lead to insulin resistance in mice. Intervention with corn husk dietary fiber can improve
the symptoms, and the best effect is achieved by the intake of high dose of SDF:IDF.

Key words: trans fatty acids, dietary fiber, mice, insulin resistance, hyperlipidemia