食品科学

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花青素抗肿瘤作用机制研究进展

崔 建,李晓岩   

  1. 东北林业大学生命科学学院,黑龙江 哈尔滨 150040
  • 出版日期:2014-07-15 发布日期:2014-07-18

Progress on Anti-tumor Mechanisms of Anthocyanins

CUI Jian, LI Xiao-yan   

  1. College of Life Sciences, Northeast Forestry University, Harbin 150040, China
  • Online:2014-07-15 Published:2014-07-18

摘要:

花青素是一类广泛存在于植物中的水溶性色素,属于黄酮类化合物,具有保肝,抗肿瘤等多种药理活性。花青素的抗肿瘤机制主要有:抗突变,抗氧化,抗炎,诱导转化,调节信号转导通路抑制肿瘤细胞增殖,诱导细胞周期阻滞,促进肿瘤细胞凋亡,诱导自噬,抗肿瘤侵袭及转移,逆转肿瘤细胞耐药性及增加对化疗的敏感性等。本文就花青素抗肿瘤分子机制的最新研究进展进行综述。

关键词: 花青素, 抗肿瘤, 信号传导, 分子靶点

Abstract:

Anthocyanins are a class of water soluble flavonoids and show some pharmacological activities such as
hepatoprotective activity and anti-tumor activity. The potential anti-tumor mechanism mainly include anti-mutagenesis,
antioxidant, anti-inflammatory, induction of differentiation, inhibiting proliferation by modulating signal transduction
pathways, inducing cell cycle arrest and stimulating apoptosis of tumor cells, inducing autophagy, anti-invasion and
metastasis, reversing drug resistance of tumor cells as well as increasing sensitivity to chemotherapy. In this review, the
latest progresses on the anti-tumor activities of anthocyanins and the underlying molecular mechanisms are summarized.

Key words: anthocyanins, anti-tumor, signal transduction, molecular target