食品科学
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崔 建,李晓岩
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CUI Jian, LI Xiao-yan
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摘要:
花青素是一类广泛存在于植物中的水溶性色素,属于黄酮类化合物,具有保肝,抗肿瘤等多种药理活性。花青素的抗肿瘤机制主要有:抗突变,抗氧化,抗炎,诱导转化,调节信号转导通路抑制肿瘤细胞增殖,诱导细胞周期阻滞,促进肿瘤细胞凋亡,诱导自噬,抗肿瘤侵袭及转移,逆转肿瘤细胞耐药性及增加对化疗的敏感性等。本文就花青素抗肿瘤分子机制的最新研究进展进行综述。
关键词: 花青素, 抗肿瘤, 信号传导, 分子靶点
Abstract:
Anthocyanins are a class of water soluble flavonoids and show some pharmacological activities such as hepatoprotective activity and anti-tumor activity. The potential anti-tumor mechanism mainly include anti-mutagenesis, antioxidant, anti-inflammatory, induction of differentiation, inhibiting proliferation by modulating signal transduction pathways, inducing cell cycle arrest and stimulating apoptosis of tumor cells, inducing autophagy, anti-invasion and metastasis, reversing drug resistance of tumor cells as well as increasing sensitivity to chemotherapy. In this review, the latest progresses on the anti-tumor activities of anthocyanins and the underlying molecular mechanisms are summarized.
Key words: anthocyanins, anti-tumor, signal transduction, molecular target
崔 建,李晓岩. 花青素抗肿瘤作用机制研究进展[J]. 食品科学, doi: 10.7506/spkx1002-6630-201413060.
CUI Jian, LI Xiao-yan. Progress on Anti-tumor Mechanisms of Anthocyanins[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201413060.
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链接本文: https://www.spkx.net.cn/CN/10.7506/spkx1002-6630-201413060
https://www.spkx.net.cn/CN/Y2014/V35/I13/310