食品科学

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小分子物质的非竞争免疫分析方法最新研究进展

陈 波,何庆华,许 杨   

  1. 1.南昌大学 食品科学与技术国家重点实验室,江西 南昌 330047;2.南昌大学中德联合研究院,江西 南昌 330047
  • 出版日期:2014-08-15 发布日期:2014-08-25

Latest Progress on Noncompetitive Immunoassays for Small Molecules

CNEN Bo, HE Qing-hua, XU Yang   

  1. 1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China;
    2. Sino-Germany Joint Research Institute, Nanchang University, Nanchang 330047, China
  • Online:2014-08-15 Published:2014-08-25

摘要:

小分子物质(即半抗原)因分子质量小、抗原表位单一,其免疫学分析方法目前多为竞争型,然而非竞争型的分析灵敏度、精确度和线性范围均优于竞争型。本文介绍了近几年小分子物质的非竞争免疫分析方法的最新研究进展,重点阐述了各类分析方法的原理、特点及应用,并对小分子物质的非竞争免疫学分析方法的发展趋势进行了展望。

关键词: 非竞争免疫分析, 半抗原, 特殊抗体

Abstract:

Although competitive immunoassays are currently used more commonly to detect small molecules due to their
low molecular weight and single epitope, noncompetitive immunoassays have better specificity, higher sensitivity and
broader linear ranges. This review describes the latest progress on various noncompetitive immunoassays for small molecules
with emphasis on their principles, characteristics and applications. Furthermore, future development trends are discussed.

Key words: noncompetitive immunoassay, haptens, specific antibody

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