纳米甘薯渣纤维素对高脂膳食大鼠肠道内环境及形态的影响

doi:10.7506/spkx1002-6630-201505033

食品科学

纳米甘薯渣纤维素对高脂膳食大鼠肠道内环境及形态的影响

陆红佳1，张磊2，刘金枝1，郭婷1，王倩倩1，刘雄1,*

1.西南大学食品科学学院，重庆 400715；2.重庆师范大学生命科学学院，重庆 401331

出版日期:2015-03-15 发布日期:2015-03-17

Effect of Cellulose Nanocrystals from Sweet Potato Residue on Intestinal Morphology and Environment in Rats Fed with High Fat Diet

LU Hongjia1, ZHANG Lei2, LIU Jinzhi1, GUO Ting1, WANG Qianqian1, LIU Xiong1,*

1. College of Food Science, Southwest University, Chongqing 400715, China;
2. College of Life Science, Chongqing Normal University, Chongqing 401331, China

Online:2015-03-15 Published:2015-03-17

摘要/Abstract

摘要：

目的：探讨纳米甘薯渣纤维素对高脂膳食大鼠肠道内环境及形态的影响。方法：选用40 只Sprague-Dawley（SD）成年雄性大鼠随机分为5 组，其中1 组大鼠喂食基础饲料（正常组），另外4 组大鼠喂食高脂饲料和添加不同粒度甘薯渣纤维素的高脂饲料，分为对照组、普通甘薯渣纤维素组（OC组）、微晶甘薯渣纤维素组（MCC组）和纳米甘薯渣纤维素组（CNC组），实验期28 d后解剖，测定大鼠采食量、体质量、盲肠组织和盲肠内容物相关指标、粪便干质量、小肠液干质量和总胆汁酸含量、小肠形态等。结果：纳米甘薯渣纤维素可以显著降低高脂膳食大鼠体质量和盲肠游离氨含量，显著升高盲肠组织各项指标、盲肠内容物短链脂肪酸含量、pH值以及小肠液总胆汁酸含量（P＜0.05），同时具有增加小肠绒毛长度及肌层厚度的作用。结论：随着甘薯渣纤维素粒度的减小，其对肠道内环境及形态作用愈加明显，说明纳米甘薯渣纤维素能有效降低SD雄性大鼠体质量，提高其肠道健康。

关键词: 纳米甘薯渣纤维素, 高脂膳食, 盲肠, 短链脂肪酸, 小肠形态

Abstract:

Objective: To investigate the effect of cellulose nanocrystals from sweet potato residue on intestinal morphology
and environment in rats fed with high fat diet. Methods: Forty mature male Sprague-Dawley (SD) rats were divided into five
groups. One group was fed with basic forage as control group (CON). The other four groups including model control (MC),
ordinary cellulose (OC), microcrystalline cellulose (MCC) and cellulose nanocrystals (CNC) groups were fed with high fat
diet supplemented with dietary fibers of different particle sizes. All rats were sacrificed after 28 days of feeding to assay the
area of cecum, the content of water, pH and short chain fatty acids in cecum contents, the dry weight of faeces and small
intestine, the total bile acid and morphology of small intestine. Results: cellulose nanocrystals could reduce body weight
in rats and the concentration of free ammonia in the cecum, and raise all the tested cecum tissue indexes, the concentration
of short chain fatty acids and pH of cecum contents and the total bile acid of small intestine significantly (P < 0.05). The
cellulose nanocrystals also could increase the small intestinal villus length and muscle layer thickness. Conclusion: Dietary
sweet potato fiber of lower granularity can promote rat intestinal environment, suggesting that cellulose nanocrystals from
sweet potato residue can effectively reduce body weight and improve the intestinal health.

Key words: cellulose nanocrystals from sweet potato residue, high fat diet, cecum, short chain fatty acids, intestinal morphology

中图分类号:

TS201.4

陆红佳1，张磊2，刘金枝1，郭婷1，王倩倩1，刘雄1,*. 纳米甘薯渣纤维素对高脂膳食大鼠肠道内环境及形态的影响[J]. 食品科学, doi: 10.7506/spkx1002-6630-201505033.

LU Hongjia1, ZHANG Lei2, LIU Jinzhi1, GUO Ting1, WANG Qianqian1, LIU Xiong1,*. Effect of Cellulose Nanocrystals from Sweet Potato Residue on Intestinal Morphology and Environment in Rats Fed with High Fat Diet[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201505033.

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纳米甘薯渣纤维素对高脂膳食大鼠肠道内环境及形态的影响

Effect of Cellulose Nanocrystals from Sweet Potato Residue on Intestinal Morphology and Environment in Rats Fed with High Fat Diet

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