食品科学

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补充D-核糖对大鼠游泳及恢复期心肌、骨骼肌高能磷酸物质的影响

王亚坤1,2,李 梦2,魏 转3,孙文敬2,4,刘敬泽2,*   

  1. 1.河北师范大学旅游系,河北 石家庄 050024;2.河北师范大学生命科学学院,河北 石家庄 050024;
    3.河北化工医药职业技术学院制药工程系,河北 石家庄 050026;4.江苏大学食品与生物工程学院,江苏 镇江 212013
  • 出版日期:2015-06-15 发布日期:2015-06-07

Effect of D-Ribose on High-Energy Phosphates in Cardiac and Skeletal Muscles of Rats during Swimming and Subsequent Recovery

WANG Yakun1,2, LI Meng2, WEI Zhuan3, SUN Wenjing2,4, LIU Jingze2,*   

  1. 1. Tourism Department, Hebei Normal University, Shijiazhuang 050024, China; 2. College of Life Science, Hebei Normal
    University, Shijiazhuang 050024, China; 3. Department of Pharmaceutical, Hebei Chemical and Pharmaceutical College,
    Shijiazhuang 050026, China; 4. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
  • Online:2015-06-15 Published:2015-06-07

摘要:

以负重游泳的大鼠为实验对象,采用高效液相色谱法同步测定肌肉样品内三磷酸腺苷(adenosinetriphosphate,ATP)及其下游代谢产物和磷酸肌酸(phosphocreatine,PCr)等6 种高能磷酸物质的含量,对补充D-核糖后大鼠心肌和腓肠肌内高能磷酸物质进行色谱分析,研究D-核糖对大鼠运动过程中及恢复期心脏及骨骼肌功能的恢复作用。结果表明:D-核糖显著提高了腓肠肌内ATP的合成速率,使机体在72 h内完全恢复运动过程中消耗的ATP,加速了运动后恢复期机体的能量供应水平恢复。同时,D-核糖显著提高了运动过程中心肌组织内ATP的含量,确保心肌组织的能量供应,维持了心脏的正常生理功能。

关键词: D-核糖, 高能磷酸物质, 高效液相色谱法, 心肌, 骨骼肌

Abstract:

In order to investigate the effect of D-ribose on the recovery of rat cardiac muscle and skeletal muscle function
during and after loaded swimming, the concentrations of high-energy phosphates such as adenosine triphosphate (ATP),
ATP metabolites and phosphocreatine (PCr) were determined by high performance liquid chromatography (HPLC). Results
showed that the synthesis rate of ATP in skeletal muscle was accelerated significantly by D-ribose; therefore, the same
amount of ATP consumed during swimming was reproduced within 72 h and the energy recovery was accelerated. At
the same time, D-ribose significantly enhanced the concentration of ATP in heart so that the energy supply to heart was
guaranteed and the normal physiological function of heart was maintained during swimming.

Key words: D-ribose, high-energy phosphate materials, high performance liquid chromatography, cardiac muscle, skeletal muscle

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