食品科学

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植物多糖通过NF-κB信号通路对巨噬细胞的免疫调节作用研究进展

陈金龙1,张月巧1,袁 娅1,吴素蕊2,明 建1,3,*   

  1. 1.西南大学食品科学学院,重庆 400715;2.中华全国供销合作总社昆明食用菌研究所,云南 昆明 650223;
    3.西南大学 国家食品科学与工程实验教学中心,重庆 400715
  • 出版日期:2015-12-15 发布日期:2015-12-24

Progress in Research on Immune-Regulatory Effects of Plant Polysaccharides on Macrophages through NF-κB Signaling Pathway

CHEN Jinlong1, ZHANG Yueqiao1, YUAN Ya1, WU Surui2, MING Jian1,3,*   

  1. 1. College of Food Science, Southwest University, Chongqing 400715, China;
    2. Kunming Edible Fungi Institute of All China Federation of Supply and Marketing Cooporatives, Kunming 650223, China;
    3. National Food Science and Engineering Experimental Teaching Center, Southwest University, Chongqing 400715, China
  • Online:2015-12-15 Published:2015-12-24

摘要:

植物多糖具有一定的免疫调节功能,作为免疫调节剂已广泛应用于医疗和保健食品行业。核转录因子κB(nuclear factor kappa B,NF-κB)是一种可以调控基因转录的核因子,对巨噬细胞内部的多种基因都有调控作用,许多研究表明植物多糖主要通过NF-κB信号传导通路诱导巨噬细胞发生免疫应答。本文介绍了NF-κB信号通路的组成和调节以及巨噬细胞表面介导植物多糖的受体活化NF-κB的机理,为深入研究植物多糖免疫调节功能提供参考。

关键词: 植物多糖, 核转录因子&kappa, B, 信号通路, 巨噬细胞, 免疫调节

Abstract:

Plant polysaccharides have immune-regulatory function and can be widely used in medical and health food
industries as immunomodulatory agents. Nuclear factor kappa B (NF-κB), as one of the nuclear factors regulating gene
transcription, plays a critical role in the regulation of multiple genes in macrophages. Many studies have shown that plant
polysaccharides induce immune response of macrophages through NF-κB signaling pathway. This review describes the
composition and regulation of NF-κB signaling pathway as well as the mechanism of NF-κB activation by the plant
polysaccharide-mediating receptor on the surface of macrophages. This review can provide a reference for further study of
plant polysaccharides.

Key words: plant polysaccharide, nuclear factor kappa B, signaling pathway, macrophages, immune regulation

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