食品科学

• 基础研究 • 上一篇    下一篇

壳聚糖修饰脂质体的环境压力和体外消化稳定性

刘玮琳,李 羚,魏富强,韩剑众*   

  1. 浙江工商大学食品与生物工程学院,浙江 杭州 310018
  • 出版日期:2016-01-15 发布日期:2016-01-15

Environmental Stress and in Vitro Digestion Stability of Chitosan-Coated Liposomes

LIU Weilin, LI Ling, WEI Fuqiang, HAN Jianzhong*   

  1. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China
  • Online:2016-01-15 Published:2016-01-15

摘要:

以壳聚糖修饰的粗脂质体和纳米脂质体为研究对象,通过加速氧化(加热)、紫外照射-自由基诱导和模拟体外消化等处理后的脂质体平均粒径、表面电荷、丙二醛含量等的变化,表征壳聚糖修饰的粗脂质体的稳定性。结果表明,经过加热、紫外照射和消化处理后,壳聚糖修饰脂质体的稳定性明显比未修饰的脂质体高,并且壳聚糖的质量浓度越高,脂质体抵抗环境压力和体外消化稳定性越强。

关键词: 脂质体, 壳聚糖, 消化, 稳定性

Abstract:

Chitosan-modified crude liposomes and nano liposomes were studied for changes in average diameter, surface
charge and malondialdehyde content after treatment with accelerated oxidation (heating), UV radiation combined with
free radical inducement and in vitro simulated digestion. The results showed that, after each treatment, the stability of the
chitosan-coated liposomes was significantly higher than bare liposomes. The higher the concentration of chitosan, the
stronger the stability of coated liposomes under environment stress and digestion.

Key words: liposomes, chitosan, digestion, stability

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