食品科学

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亚油酸氧化产物——白细胞毒素和白细胞毒素二醇的研究进展

宋 慧1,2,耿志明1,*,任 双1,2,王道营1,杜盼盼1,2,张牧焓1,孙 冲1,刘 芳1,徐为民1   

  1. 1.江苏省农业科学院农产品加工研究所,江苏 南京 210014;
    2.南京农业大学 肉品加工与质量控制教育部重点实验室,江苏 南京 210095
  • 出版日期:2016-03-15 发布日期:2016-03-17

Progress in Studies on Oxidation Products of Linoleic Acid Leukotoxin and Leukotoxin Diols

SONG Hui1,2, GENG Zhiming1,*, REN Shuang1,2, WANG Daoying1, DU Panpan1,2, ZHANG Muhan1, SUN Chong1, LIU Fang1, XU Weimin1   

  1. 1. Institute of Agricultural Products Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China;
    2. Key Laboratory of Meat Processing and Quality Control, Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China
  • Online:2016-03-15 Published:2016-03-17

摘要:

白细胞毒素(leukotoxin,Ltx)和白细胞毒素二醇(leukotoxin diol,Ltxd)是亚油酸的氧化产物,研究表明,Ltx和Ltxd具有细胞毒性,与哺乳动物多种疾病相关,而外源性Ltx和Ltxd的摄入可以引起哺乳动物内分泌紊乱。本文系统综述Ltx和Ltxd的发现、形成机理、病理和生理学意义、毒性作用以及检测方法,并对未来的研究重点进行展望。

关键词: 亚油酸, 脂质氧化, 白细胞毒素, 白细胞毒素二醇

Abstract:

Leukotoxin (Ltx) and leukotoxin diol (Ltxd) are oxidation products of linoleic acid (LA). The existing studies
indicate that both Ltx and Ltxd are cytotoxic and associated with a number of mammalian diseases. Exogenous Ltx and Ltxd
can disrupt the endocrine function in female rats. The present paper reviews the recent progress made in the studies of Ltx
and Ltxd with respect to discovery, mechanisms of formation, pathological and physiological significance, toxicological
effects and analytical methods. Moreover, further studies in this area are also suggested.

Key words: linoleic acid, lipid oxidation, leukotoxin, leukotoxin diol

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